Publications by authors named "Devadatta Gosavi"

Authors are often faced with the decision of whether to maximize traditional impact metrics or minimize costs when choosing where to publish the results of their research. Many subscription-based journals now offer the option of paying an article processing charge (APC) to make their work open. Though such "hybrid" journals make research more accessible to readers, their APCs often come with high price tags and can exclude authors who lack the capacity to pay to make their research accessible.

View Article and Find Full Text PDF
Article Synopsis
  • The IRES RNA of bovine viral diarrhoea virus (BVDV) is crucial for the cap-independent translation necessary for viral replication and pathogenesis.
  • Our research used advanced RNA structure probing techniques to unveil that BVDV IRES RNA has a complex modular architecture with three distinct domains, including a unique H-type pseudoknot in domain III.
  • Additionally, our analysis indicated that this pseudoknot form is evolutionarily conserved across various species, highlighting its importance for the effective translation of the viral genome.
View Article and Find Full Text PDF

Human coronaviruses (HCoV) are causative agents of mild to severe intestinal and respiratory infections in humans. In the last 15 years, we have witnessed the emergence of three zoonotic, highly pathogenic HCoVs. Thus, early and accurate detection of these viral pathogens is essential for preventing transmission and providing timely treatment and monitoring of drug resistance.

View Article and Find Full Text PDF

Coronaviruses are the causative agents of mild to severe respiratory and intestinal infections in humans. They are the largest RNA viruses, which genomes and encoded RNAs are known to fold into the highly-order structures that play essential roles in the viral replication and infectivity cycle. The recent outbreaks of new pathogenic coronaviruses steered researchers’ attention into the possibility of targeting their RNAs directly with novel RNA-specific drugs and therapeutic strategies.

View Article and Find Full Text PDF