Altered levels of seminal nitric oxide, nitric oxide synthase, and enzymatic antioxidants and their association with sperm function in infertile subjects.

Objective: To investigate the association between specific reactive nitrogen species and sperm function among infertile subjects.

Design: Controlled trial.

Setting: Fertility clinic at the National Institute of Health and Family Welfare, New Delhi, India.

Sperm function and seminal oxidative stress as tools to identify sperm pathologies in infertile men.

Routine semen analysis, which includes assessment of sperm motility, viability, and morphology, does not always provide complete diagnostic information as men demonstrating standard scores on these specific parameters sometimes remain infertile. In infertile men who had been subgrouped on the basis of sperm count, motility, morphology, and presence of leukocytes, an evaluation of sperm function and reactive oxygen species (ROS) was found to be effective tools to detect sperm pathologies.