Lactogenic activity of (Linn.) fruit with special reference to the estimation of serum prolactin and cortisol level in nursing rats.

Aim: The objective of the study was to investigate the lactogenic activity of methanolic extract of (L.) fruit (MTLF) on rats.

Subjects And Methods: Nursing rats (200-250 g) with their suckling pups were selected and were divided into five groups ( = 6).

Chemopreventive potential of Apium leptophyllum (Pers.) against DMBA induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers in Swiss mice.

Aim: The study was designed to investigate the chemopreventive potential of flavonoidal fractions of Apium leptophyllum fruits (FFALF) on Swiss mice.

Materials And Methods: Skin tumor or papilloma was developed by topical application of DMBA (25 μg in 0.1 ml acetone) on intrascapular region of mice, twice weekly for 8 weeks.

Evaluation of antiulcer potential of Mimusops hexandra in experimental gastro duodenal ulcers.

The study was aimed to investigate antiulcer effects of acetone extract and its different fractions Mimusops hexandra against experimental gastro-duodenal ulcers. 80% acetone extract of stem bark of Mimusops hexandra (Extract A, p.o.

Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora.

Aim Of The Study: Saponins from Helicteres isora have previously been shown to exert antidiabetic effects. The present study explored the underlying mechanisms in C2C12 skeletal muscle cells.

Materials And Methods: C2C12 cells were incubated with saponins and sapogenin followed by Western blotting and immunofluorescence analysis.

Effect of saponins from Helicteres isora on lipid and glucose metabolism regulating genes expression.

Ethnopharmacological Relevance: We characterized saponins as active constituents from traditionally used antidiabetic plant Helicteres isora.

Aim Of The Study: To evaluate the changes in the gene expression of the glucose and lipid metabolism regulating genes in C57BL/KsJ-db/db mice.

Materials And Methods: C57BL/KsJ-db/db mice were divided into four different groups; one diabetic control, the mice in other three groups were treated with methanol extract (100 mg/kg), saponins (100 mg/kg) and pioglitazone (30 mg/kg) for 14 days.

Experimental evidence for the cardioprotective effects of red wine.

Both epidemiological and experimental studies have revealed that intake of wine, particularly red wine, in moderation protects cardiovascular health; however, the experimental basis for such an action is not fully understood. Because all types of red wine contain varying amounts of alcohol and antioxidants, it is likely that the cardioprotective effect of red wine is due to both these constituents. In view of its direct action on the vascular smooth muscle cells, alcohol may produce coronary vasodilation in addition to attenuating oxidative stress by its action on the central nervous system.

Angiogenesis--a new target for future therapy.

Development of blood vessels from in situ differentiating endothelial cells (EC) is called vasculogenesis, whereas sprouting of new blood vessels from the pre-existing ones is termed angiogenesis or neovascularisation. Angiogenesis, the growth of new blood vessels, is essential during tissue repair, foetal development, and female reproductive cycle. In contrast, uncontrolled angiogenesis promotes tumor and retinopathies, while inadequate angiogenesis can lead to coronary artery disease.

A novel use of methylene blue as a pharmacological tool.

Introduction: A new use of methylene blue as an ulcerogenic agent and the mechanisms involved were identified with an objective to exploit methylene blue as a pharmacological tool to study investigational antiulcer agents.

Methods: Ulcerogenic potential was assessed using electron microscopy and measurement of an ulcer index after administering methylene blue (5-125 mg kg(-1), p.o.

Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.

We have studied the effects of chronic treatment with cromakalim (75 ug kg(-1) per day) and glibenclamide (20 mg kg(-1) per day) in alloxan-induced diabetic rats. Injection of alloxan (60 mg kg(-1)/i.v.