Plasmon-Enhanced Fluorescence of Single Extracellular Vesicles Captured in Arrayed Aluminum Nanoholes.

Extracellular vesicles (EVs) are nanoparticles encapsulated with a lipid bilayer, and they constitute an excellent source of biomarkers for multiple diseases. However, the heterogeneity in their molecular compositions constitutes a major challenge for their recognition and profiling, thereby limiting their application as an effective biomarker. A single-EV analysis technique is crucial to both the discovery and the detection of EV subpopulations that carry disease-specific signatures.

Optimal voltage and frequency control strategy for renewable-dominated deregulated power network.

Maintaining stable voltage and frequency regulation is critical for modern power systems, particularly with the integration of renewable energy sources. This study proposes a coordinated control strategy for voltage and frequency in a deregulated power system comprising six Generation Companies (GENCOs) and six Distribution Companies (DISCOs). The system integrates thermal, diesel, wind, solar photovoltaic (PV), and hydroelectric sources.

Dimethylamine Bismuth Iodide: A Lead-Free Perovskite Enabling Ultra-Sensitive UVC Photodetection with Low Operating Voltage and High Detectivity.

Ultraviolet (UV) photodetectors (PDs) are essential for various applications, but traditional materials face challenges in cost, fabrication, and performance. This study introduces dimethylamine bismuth iodide (DMABI) as a promising lead-free perovskite for UV PDs, particularly in the UVC region. DMABI demonstrates exceptional device parameters, including an ultralow dark current of 0.

Management of high-dose olanzapine poisoning in a young child under limited resource setting: a case report from Nepal.

Introduction: Olanzapine, an atypical antipsychotic, is widely used for treating psychiatric conditions such as schizophrenia and bipolar disorder. Accidental overdose in children is rare but can lead to severe clinical effects. This case report discusses the management of a 5-year-old male who accidently ingested 180 mg of olanzapine, the highest reported dose in a child around 5 year.

Signalling and molecular pathways, overexpressed receptors of colorectal cancer and effective therapeutic targeting using biogenic silver nanoparticles.

Increasing morbidity and mortality in CRC is a potential threat to human health. The major challenges for better treatment outcomes are the heterogeneity of CRC cases, complicated molecular pathway cross-talks, the influence of gut dysbiosis in CRC, and the lack of multimodal target-specific drug delivery. The overexpression of many receptors in CRC cells may pave the path for targeting them with multiple ligands.

Exploring aluminum as a solid thermal storage medium for solar cooking application: An experimental investigation coupled with numerical modeling using OpenFOAM.

The intermittent nature of solar energy presents a significant challenge to its reliability, particularly in applications that require a consistent energy supply, such as cooking. This issue is especially critical in emerging economies with abundant solar resources, where sustainable energy solutions are needed to reduce reliance on traditional fuels. To address this challenge, this study introduces a novel solar thermal storage (STS), utilizing a metal-based material to accumulate and retain heat for off-sunshine hour cooking.

Enhancing load frequency control and automatic voltage regulation in Interconnected power systems using the Walrus optimization algorithm.

This paper introduces the Walrus Optimization Algorithm (WaOA) to address load frequency control and automatic voltage regulation in a two-area interconnected power systems. The load frequency control and automatic voltage regulation are critical for maintaining power quality by ensuring stable frequency and voltage levels. The parameters of fractional order Proportional-Integral-Derivative (FO-PID) controller are optimized using WaOA, inspired by the social and foraging behaviors of walruses, which inhabit the arctic and sub-arctic regions.

A young female's battle with toxic epidermal necrolysis induced by NSAIDs: a case report.

Introduction: Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous reaction often triggered by medications or infections, characterized by extensive epidermal detachment and mucosal involvement. This condition poses a high risk of morbidity and mortality, requiring prompt recognition and treatment.

Case Presentation: An 18-year-old Asian female from eastern Nepal presented with nonitchy red spots, high fever, and significant discomfort following the administration of ibuprofen for minor sores.

Ship recycling process in Bangladesh and a survey-based risk assessment with mitigation proposal.

Ship recycling industries play a significant role in the economic development of South Asian countries, including Bangladesh. In the wake of entering the Hong Kong Convention (HKC) in June 2025, the industry aims to improve its overall safety standards cost-effectively. However, due to the restrictive nature of the industry, solutions based on field surveys are limited.

Initial Trans-Arterial Chemo-Embolisation (TACE) Is Associated with Similar Survival Outcomes as Compared to Upfront Percutaneous Ablation Allowing for Follow-Up Treatment in Those with Single Hepatocellular Carcinoma (HCC) ≤ 3 cm: Results of a Real-World Propensity-Matched Multi-Centre Australian Cohort Study.

Percutaneous ablation is recommended in Barcelona Clinic Liver Cancer (BCLC) stage 0/A patients with HCC ≤3 cm as a curative treatment modality alongside surgical resection and liver transplantation. However, trans-arterial chemo-embolisation (TACE) is commonly used in the real-world as an initial treatment in patients with single small HCC in contrast to widely accepted clinical practice guidelines which typically describe TACE as a treatment for intermediate-stage HCC. We performed this real-world propensity-matched multi-centre cohort study in patients with single HCC ≤ 3 cm to assess for differences in survival outcomes between those undergoing initial TACE and those receiving upfront ablation.

Proximity-induced FRET and charge-transfer between quantum dots and curcumin enable reversible thermochromic hybrid polymeric films.

This study introduces a novel strategy for developing reversible thermochromic fluorescent films by precisely controlling the nanoscale proximity of boron nitride quantum dots and curcumin molecules within a poly(3-hydroxybutyrate) matrix. The synergistic interaction and Förster resonance energy transfer between these fluorophores result in an energy transfer efficiency of ∼94%. This approach enables tunable color changes in response to temperature variations, governed by the segmental mobility of polymer chains.

Lung carcinoma with adrenal metastasis and inferior vena cava thrombosis in an elderly patient with decompensated chronic liver disease: a case report.

Introduction: Managing patients with complex comorbidities poses significant diagnostic and therapeutic challenges. This case report details a 65-year-old male with a history of decompensated chronic liver disease (CLD) and portal hypertension, who presented with symptoms suggestive of liver disease exacerbation. He was later diagnosed with primary lung malignancy and extensive thrombosis, including the inferior vena cava (IVC) and heart chambers, a rare finding.

Correlation of Mean Platelet Volume and Red Cell Distribution Width With HbA1c and Its Association With Microvascular Complications in Type 2 Diabetes Mellitus: A Cross-Sectional Study at a Tertiary Hospital in India.

Introduction: Diabetes mellitus type 2 (T2DM) is a metabolic disorder, and its prevalence is rising worldwide. The objective of the study was to investigate the association between mean platelet volume (MPV) and red cell distribution width (RDW) and the glycemic control marker HbA1c. So MPV and RDW could be used as prognostic indicators of deterioration of gluco-regulation in diabetes mellitus type 2 and the associated microvascular complications.

Encapsulation of 4-oxo--(4-hydroxyphenyl) retinamide in human serum albumin nanoparticles promotes EZH2 degradation in preclinical neuroblastoma models.

Neuroblastoma is the most prevalent and aggressive solid tumor that develops extracranially in children between the ages of 0-14 years, which accounts for 8-10% of all childhood malignancies and ∼15% of pediatric cancer-related mortality. The polycomb repressive complex 2 (PRC2) protein, EZH2, is overexpressed in neuroblastoma and mediates histone H3 methylation at lysine 27 (K27) positions through its methyl transferase activity and is a potential epigenetic silencer of many tumor suppressor genes in cancer. Phosphorylation of EZH2 decreases its stability and leads to proteasomal degradation.