Publications by authors named "Despoina Karagianni"
Article Synopsis
- Researchers studied the cellular structure of melanoma tumors and their changes when treated with immune checkpoint blockade (ICB) to understand why some patients resist this therapy.
- They found that a specific cell type with a mesenchymal-like (MES) state, which is associated with resistance to treatment, was more common in patients who did not respond to ICB.
- The study identified TCF4 as a key regulator that controls this resistance by suppressing other important immune functions, and targeting TCF4 could enhance the effectiveness of both ICB and other therapies in melanoma treatment.
Background: Cancer cells remodel their local physical environment through processes of matrix reorganisation, deposition, stiffening and degradation. Urokinase-type plasminogen activator (uPA), which is encoded by the gene, is an extracellular proteolytic enzyme known to be involved in cancer progression and tumour microenvironment (TME) remodelling. Perturbing uPA therefore has a strong potential as a mechano-based cancer therapy.
View Article and Find Full Text PDFBackground: This study investigated the relationship between exclusive breastfeeding and breastfeeding duration, and maternal psychological well-being in the perinatal period.
Methods: A longitudinal study involving a retrospective follow-up of a group of 1080 women from pregnancy to the 1st year postpartum, who gave birth during the 5-year period between January 2014 and January 2019 in Athens, Greece, was designed. Women's history and two psychometric tools-the Edinburg Postpartum Depression Scale (EPDS) and the Patient Health Questionnaire-9 (PHQ-9) administered at 5-time points-were used for data collection.