Effect of kaolin on productivity, anatomical and biochemical responses to water deficit in Pelargonium graveolens grown in sandy soil.

The objective of this study was to examine the response of geranium plants to different irrigation levels (100%, 80%, and 60% based on ET) and Kaolin application rates (0, 100, 200 and 300 ppm) during 2022 and 2023 seasons, at Aly Mobarak Experimental Farm, Horticulture Research Station, located at El-Bustan site, El-Behiera Governorate, Egypt, by using a two-way factorial analysis experimental design. The results revealed that water deficit significantly reduced most studied traits. Irrigation level at 60% based on ET exhibited poorest performance on growth parameters and decreased fresh yield and essential oil yield by 27.

Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis.

Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction. The leaves of have been used for inflammation-related disease management in traditional medicine. Additionally, the downregulation of NF-κB and the MMP/TIMP-1 ratio has been shown to protect against OA.

Synergistic Influence of Fungi Inoculation with Nanoparticle Foliar Application Enhances Chili ( L.) Antioxidant Enzymes, Anatomical Characteristics, and Productivity under Cold-Stress Conditions.

In this study, we aimed to evaluate the effects of fungus (AMF) inoculation, foliar application of zinc oxide and selenium nanoparticles (ZnO-NPs and Se-NPs), and their combined interactions on the growth and productivity of chili pepper under cold-stress conditions. Two field experiments were successfully conducted during the winter seasons of 2021 and 2022 in an experimental field at the Faculty of Agriculture, Cairo University, Giza, Egypt. The results showed that, under cold stress, the combination of AMF inoculation and ZnO-NPs + Se-NPs as a foliar spray increased the average fruit weight by 92.

Metabolic profiling and biological potential of the marine sponge associated sp. UR67 along with docking studies.

This work was performed to dig into the phytochemical composition and bioactivities of sp. UR67 associated with the marine sponge sp. It was fermented in suspension and immobilised in calcium alginate bead cultures.

Chemical and biological studies on the soft coral sp.

Soft corals belonging to the family Nephtheidae have been appreciated as marine sources of diverse metabolites with promising anticancer potential. In view of that, the current work investigates the anti-proliferative potential of the crude extract, different fractions, and green synthesized silver nanoparticles (AgNPs) of the Red Sea soft coral, sp. against a panel of tumor cell lines.

NS3 helicase inhibitory potential of the marine sponge .

In the current study, an investigation of the activity of the total extract of the marine sponge and its different fractions against the hepatitis C virus (HCV) was pursued. The results revealed that the ethyl acetate fraction exhibited the highest anti-HCV activity, with an IC value of 12.6 ± 0.

Cytotoxic potential of sp.-derived actinomycetes supported by metabolomics analysis.

Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach.

The Red Sea marine sponge : metabolomic profiling and cytotoxic potential supported by studies.

The current study discusses the chemical composition of the marine sponge using LC-HRESIMS. The metabolomic profiling resulted in the annotation of 17 metabolites of different chemical classes. Additionally, evaluation of the cytotoxic activities of the total extract and different fractions were carried out against three different cell lines where the -butanol fraction exhibited the highest cytotoxic effects against HepG-2, MCF-7 and CACO-2 cell lines with IC values of 9.

Natural products potential of Dictyoceratida sponges-associated micro-organisms.

The marine environment represents one of the most underexplored environments in the world. Marine sponges have a higher taxonomic diversity according to definite environmental conditions. They have been considered interesting sources for bioactive compounds.

Natural metabolites from the soft coral sp. as potential SARS-CoV-2 main protease inhibitors.

The ongoing spread of SARS-CoV-2 has created a growing need to develop effective antiviral treatments; therefore, this work was undertaken to delve into the natural metabolites of the Red Sea soft coral sp. (family Nephtheidae) as a source of potential anti-COVID-19 agents. Overall, a total of 14 structurally diverse minor constituents were isolated and identified from the petroleum ether fraction of sp.

Antiproliferative potential of aerial parts family lamiaceae (labiatae), supported by phytochemical investigation and molecular docking study.

The current biologically guided study aimed the investigation of cytotoxic activity, identification of the phytochemical content of aerial parts and supporting this activity by a molecular docking study. Aqueous fraction demonstrated the most potent cytotoxic effect against CACO-2 with IC = 0.067 ± 0.

Multitarget studies of , family against SARS-CoV-2 supported by molecular dynamics simulation.

The novel strain of human coronavirus, emerged in December 2019, which has been designated as SARS-CoV-2, causes a severe acute respiratory syndrome. Since then, it has arisen as a serious threat to the world public health. Since no approved vaccines or drugs has been found to efficiently stop the virulent spread of the virus, progressive inquiries targeting these viruses are urgently needed, especially those from plant sources.

In vivo anti-inflammatory and hepatoprotective activities of (Forssk.) aerial parts in relation to its phytomolecules.

A total methanolic extract and its sub-extracts of (Forssk.) aerial parts were subjected to acute toxicity, anti-inflammatory, and hepatoprotective investigations. The methanolic extract was safe upto 3 g/kg on mice.

Potential of metabolites against SARS-CoV-2 main protease supported by docking studies.

COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds.

Isolation and characterization of novel acetylcholinesterase inhibitors from L. leaves.

Metabolic profiling of the crude methanolic extract of leaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides and tetrapyrrole pigments. A phytochemical study of the ethyl acetate fraction resulted in the identification of three known compounds, namely carpachromene (1), alpha amyrine acetate (2), and mucusoside (3) together with one new fatty acid glycoside, named 2--α-l-rhamnopyranosyl-hexacosanoate-β-d-glucopyranosyl ester (4). The compounds were identified using 1D, 2D NMR, and HR-ESIMS techniques as well as comparison to other literature.

Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery.

Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. Sponges which belong to the order Dictyoceratida are distinctly classified into 5 families: Dysideidae, Irciniidae, Spongiidae, Thorectidae, and Verticilliitidae. In this review, compounds isolated from Dictyoceratida sponges were discussed with their biological potential within the period 2013 to December 2019.

Anti-epileptic potential, metabolic profiling and in silico studies of the aqueous fraction from benth, family .

The current study aimed to investigate the anti-epileptic potential of the ethanol extract and its different fractions from the plant, . The results revealed that the aqueous fraction with the latest onset of myoclonic convulsions (1095 ± 45**** s) was the most biologically active one. This was followed by LC-HR-MS-coupled metabolic profiling which led to dereplication of 8 compounds from that fraction.

Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Sp. Supported by Metabolomics Analysis and Docking Studies.

Background: Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest.

Purpose: To investigate the anti-inflammatory potential of the soft coral, sp., in its bulk and silver nanostructure.

Metabolomic profiling and biological investigation of (Silva Manso) leaves, family Bignoniaceae.

Both ethyl acetate and aqueous fractions of leaves exhibited noteworthy antioxidant and nephroprotective activities against carbon tetrachloride (CCl)-induced nephrotoxicity in rats, as evidenced by the remarkable improvements of renal serum biomarkers and histopathological features. Additionally, the ethyl acetate fraction displayed a prominent antitrypanosomal activity against ; consequently, the leaves were subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, ten metabolites were characterized, mostly dominated by flavonoids.

Metabolomics analysis and biological investigation of three Malvaceae plants.

Introduction: Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery.

Objective: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H.

Recent Updates on Corals from Nephtheidae.

Marine natural products display a wide range of biological activities, which play a vital role in the innovation of lead compounds for the drug development. Soft corals have been ranked at the top in regard to the discovery of bioactive metabolites with potential pharmaceutical applications. Many of the isolated cembranoids revealed diverse biological activities, such as anticancer, antidiabetic and anti-osteoporosis.

New bioactive metabolites from the elicited marine sponge-derived bacterium Actinokineospora spheciospongiae sp. nov.

Several approaches have been dedicated to activate the cryptic gene clusters in the genomes of actinomycetes for the targeted discovery of new fascinating biomedical lead structures. In the current study, N-acetylglucosamine was used to maximize the chemical diversity of sponge-derived actinomycete Actinokineospora spheciospongiae sp. nov.

Metabolomic profiling and anti-infective potential of and (Family Asteraceae).

The present study evaluates the chemical composition of and based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for , while amides and phenolic acid derivatives were characteristic for . These results highlight the chemical potential of and Furthermore, the ethyl acetate fraction of showed a significant antimalarial activity with IC values of 21.