Insertable, dual-density dielectric barrier for acoustic pressure level reduction in a high-performance human head-only MRI system.

We report use of a dual-density dielectric barrier surrounding a detachable high-pass radiofrequency (RF) birdcage coil to achieve an order-of-magnitude reduction of acoustic noise in a high-performance head gradient system. The barrier consisted of a 4.5 mm-thick mass-loaded vinyl and a 6 mm-thick polyurethane foam.

Human prostate MRI at ultrahigh-performance gradient: A feasibility study.

Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system.

Methods: In this local institutional review board-approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 mT/m and slew rate of 500 T/m/s.

Revealing tumor microstructure with oscillating diffusion encoding MRI in pre-surgical and post-treatment glioma patients.

Purpose: We hypothesized that the time-dependent diffusivity at short diffusion times, as measured by oscillating gradient spin echo (OGSE) diffusion MRI, can characterize tissue microstructures in glioma patients.

Theory And Methods: Five adult patients with known diffuse glioma, including two pre-surgical and three with new enhancing lesions after treatment for high-grade glioma, were scanned in an ultra-high-performance gradient 3.0T MRI system.

Simulation guided design of the MRcollar: a MR compatible applicator for deep heating in the head and neck region.

Purpose: To develop a head and neck hyperthermia phased array system compatible with a 1.5 T magnetic resonance (MR) scanner for noninvasive thermometry.

Methods: We designed a dielectric-parabolic-reflector antenna (DiPRA) based on a printed reflector backed dipole antenna and studied its predicted and measured performance in a flat configuration (30 mm thick water bolus and muscle equivalent layer).

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia.

Clinical trials have demonstrated the therapeutic benefits of adding radiofrequency (RF) hyperthermia (HT) as an adjuvant to radio- and chemotherapy. However, maximum utilization of these benefits is hampered by the current inability to maintain the temperature within the desired range. RF HT treatment quality is usually monitored by invasive temperature sensors, which provide limited data sampling and are prone to infection risks.

Highly efficient head-only magnetic field insert gradient coil for achieving simultaneous high gradient amplitude and slew rate at 3.0T (MAGNUS) for brain microstructure imaging.

Purpose: To develop a highly efficient magnetic field gradient coil for head imaging that achieves 200 mT/m and 500 T/m/s on each axis using a standard 1 MVA gradient driver in clinical whole-body 3.0T MR magnet.

Methods: A 42-cm inner diameter head-gradient used the available 89- to 91-cm warm bore space in a whole-body 3.

Referenced MR thermometry using three-echo phase-based fat water separation method.

A three-point image reconstruction method for internally referenced MR thermometry was developed. The technique exploits the fact that temperature-induced changes in the water resonance frequency are small relative to the chemical shift difference between water and fat signals. This property enabled the use of small angle approximations to derive an analytic phase-based fat-water separation method for MR thermometry.

Exploration of MR-guided head and neck hyperthermia by phantom testing of a modified prototype applicator for use with proton resonance frequency shift thermometry.

Magnetic resonance thermometry (MRT) offers non-invasive temperature imaging and can greatly contribute to the effectiveness of head and neck hyperthermia. We therefore wish to redesign the HYPERcollar head and neck hyperthermia applicator for simultaneous radio frequency (RF) heating and magnetic resonance thermometry. In this work we tested the feasibility of this goal through an exploratory experiment, in which we used a minimally modified applicator prototype to heat a neck model phantom and used an MR scanner to measure its temperature distribution.

Validation of MR thermometry: method for temperature probe sensor registration accuracy in head and neck phantoms.

Purpose: Magnetic resonance thermometry (MRT) is an attractive means to non-invasively monitor in vivo temperature during head and neck hyperthermia treatments because it can provide multi-dimensional temperature information with high spatial resolution over large regions of interest. However, validation of MRT measurements in a head and neck clinical set-up is crucial to ensure the temperature maps are accurate. Here we demonstrate a unique approach for temperature probe sensor localisation in head and neck hyperthermia test phantoms.

MRI of Thiel-embalmed human cadavers.

Purpose: To explain the observed considerable loss of signal and contrast when Thiel-embalmed human cadavers are imaged using clinical magnetic resonance imaging (MRI) sequences, especially those based on spin-echo MRI.

Materials And Methods: All cadavers were imaged with a medical 1.5T scanner using standard MRI sequences.

Fat-referenced MR thermometry in the breast and prostate using IDEAL.

Purpose: To demonstrate a three-echo fat-referenced MR thermometry technique that estimates and corrects for time-varying phase disturbances in heterogeneous tissues.

Materials And Methods: Fat protons do not exhibit a temperature-dependent frequency shift. Fat-referenced thermometry methods exploit this insensitivity and use the signal from fat to measure and correct for magnetic field disturbances.

Local specific absorption rate in high-pass birdcage and transverse electromagnetic body coils for multiple human body models in clinical landmark positions at 3T.

Purpose: To use electromagnetic (EM) simulations to study the effects of body type, landmark position, and radiofrequency (RF) body coil type on peak local specific absorption rate (SAR) in 3T magnetic resonance imaging (MRI).

Materials And Methods: Numerically computed peak local SAR for four human body models (HBMs) in three landmark positions (head, heart, pelvic) were compared for a high-pass birdcage and a transverse electromagnetic 3T body coil. Local SAR values were normalized to the IEC whole-body average SAR limit of 2.

Motion robust magnetic susceptibility and field inhomogeneity estimation using regularized image restoration techniques for fMRI.

In functional MRI, head motion may cause dynamic nonlinear field-inhomogeneity changes, especially with large out-of-plane rotations. This may lead to dynamic geometric distortion or blurring in the time series, which may reduce activation detection accuracy. The use of image registration to estimate dynamic field inhomogeneity maps from a static field map is not sufficient in the presence of such rotations.

Formulation of current density weighted indices for correspondence between functional MRI and electrocortical stimulation maps.

Objective: Accurate localization of functionally significant brain regions reduces risks of post-operative neurological deficits. The gold standard for presurgical brain mapping is subdural electrocortical stimulation (ECS), which is an open-cranium surgical procedure. Functional MRI (fMRI) may be a noninvasive alternative if it can be shown that fMRI and ECS maps are spatially consistent.

Regularized field map estimation in MRI.

In fast magnetic resonance (MR) imaging with long readout times, such as echo-planar imaging (EPI) and spiral scans, it is important to correct for the effects of field inhomogeneity to reduce image distortion and blurring. Such corrections require an accurate field map, a map of the off-resonance frequency at each voxel. Standard field map estimation methods yield noisy field maps, particularly in image regions with low spin density.

Concurrent correction of geometric distortion and motion using the map-slice-to-volume method in echo-planar imaging.

The accuracy of measuring voxel intensity changes between stimulus and rest images in fMRI echo-planar imaging (EPI) data is severely degraded in the presence of head motion. In addition, EPI is sensitive to susceptibility-induced geometric distortions. Head motion causes image shifts and associated field map changes that induce different geometric distortion at different time points.

Comprehensive mathematical simulation of functional magnetic resonance imaging time series including motion-related image distortion and spin saturation effect.

There has been vast interest in determining the feasibility of functional magnetic resonance imaging (fMRI) as an accurate method of imaging brain function for patient evaluations. The assessment of fMRI as an accurate tool for activation localization largely depends on the software used to process the time series data. The performance evaluation of different analysis tools is not reliable unless truths in motion and activation are known.

Zero and first-order phase shift correction for field map estimation with dual-echo GRE using bipolar gradients.

A simple phase error correction technique used for field map estimation with a generally available dual-echo gradient-echo (GRE) sequence is presented. Magnetic field inhomogeneity maps estimated using two separate GRE volume acquisitions at different echo times are prone to dynamic motion errors between acquisitions. By using the dual-echo sequence, the data are collected during two back-to-back readout gradients in opposite polarity after a single radio frequency pulse, and interecho motion artifacts and alignment errors in field map estimation can be factored out.

Improved map-slice-to-volume motion correction with B0 inhomogeneity correction: validation of activation detection algorithms using ROC curve analyses.

Head motion is a significant source of error in fMRI activation detection and a common approach is to apply 3D volumetric rigid body motion correction techniques. However, in 2D multislice fMRI, each slice may have a distinct set of motion parameters due to inter-slice motion. Here, we apply an automated mutual information based slice-to-volume rigid body registration technique on time series data synthesized from a T2 MRI brain dataset with simulated motion, functional activation, noise and geometric distortion.