Publications by authors named "Desmond A Young"
Article Synopsis
- The study investigated how increased carbon dioxide (hypercapnia) and low oxygen levels (hypoxia) during apneas affect heart rate, specifically focusing on bradycardia (slowed heart rate).
- Researchers hypothesized that apneas with both hypercapnia and hypoxia would lead to more significant bradycardia compared to either condition alone.
- Results showed that hypoxia was the main factor causing bradycardia, with combined hypercapnia and hypoxia leading to similar heart rate responses as hypoxia alone.
Purpose: We conducted a meta-analysis to determine the effect of hyperoxia on muscle sympathetic nerve activity in healthy individuals and those with cardio-metabolic diseases.
Methods: A comprehensive search of electronic databases was performed until August 2022. All study designs (except reviews) were included: population (humans; apparently healthy or with at least one chronic disease); exposures (muscle sympathetic nerve activity during hyperoxia or hyperbaria); comparators (hyperoxia or hyperbaria vs.
We report the preparation and characterisation of a series of novel non-heme N4-tetradentate Mn(OTf)2 complexes of the type, [(L)MnOTf2], where L = R,R and S,S enantiomers of BPMCN, its 6-methyl and 6-bromo derivatives as well as the novel ligand BMIMCN (BPMCN = N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-(R,R/S,S)-1,2-diaminocyclohexane, BMIMCN = N,N'-dimethyl-N,N'-bis(1-methyl-2-imidazolemethyl)-(R,R/S,S)-1,2-diaminocyclohexane). Solid state structural analysis of the BMIMCN-ligated Mn-triflate complexes (R,R-C4 and S,S-C4) revealed opposite helicity but identical metal site accessibility. This feature was exploited in the catalytic oxidation of primary and secondary alcohols, with hydrogen peroxide as oxidant and acetic acid as co-catalyst.
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