Publications by authors named "Desiree R Delgadillo"

The brain-gut-microbiome (BGM) system plays an influential role on mental health. We characterized BGM patterns related to resilience using fecal samples and multimodal MRI. Data integration analysis using latent components showed the high resilience phenotype was associated with lower depression and anxiety symptoms, higher frequency of bacterial transcriptomes (related to environmental adaptation, genetic propagation, energy metabolism, anti-inflammation), increased metabolites (N-acetylglutamate; dimethylglycine), and cortical signatures (increased resting state functional connectivity between reward circuits and sensorimotor networks; decreased grey matter volume and white matter tracts within the emotion regulation network).

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Article Synopsis
  • The study investigates the biological basis of stress reactivity (SR) differences in individuals, focusing on irritable bowel syndrome (IBS) patients and healthy controls (HCs) to understand how these differences impact their health.
  • It uses data from 291 participants, applying methods like transcriptomics profiling and brain imaging to categorize individuals into high and low SR groups and analyze their differences.
  • Results indicate that those with high SR have greater sympathetic nervous system activation and brain changes linked to heightened stress responses, suggesting that this increased activity could be a risk factor for IBS and may inform personalized treatment approaches.
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Objective: Emerging research has connected abundances of specific bacteria to differences in psychosocial behaviors in animals and adult humans. However, research assessing mind-microbiome associations in children is sparse with extant work primarily focused on populations with autism, making it unclear whether links are also present in typically developing children. The current study fills this gap by examining associations between prosocial-self-regulating temperaments (effortful control; EC) and the gut microbiome in typically developing children.

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