Publications by authors named "Desiree Genovese"
Background: Causes and mechanisms underlying cancer cachexia are not fully understood, and currently, no therapeutic approaches are available to completely reverse the cachectic phenotype. Interleukin-6 (IL-6) has been extensively described as a key factor in skeletal muscle physiopathology, exerting opposite roles through different signalling pathways.
Methods: We employed a three-dimensional ex vivo muscle engineered tissue (X-MET) to model cancer-associated cachexia and to study the effectiveness of selective inhibition of IL-6 transignalling in counteracting the cachectic phenotype.
Article Synopsis
- * A new tool called 3D eX vivo muscle engineered tissue (X-MET) was developed to study how mechanical stimuli can improve heart function after ischemia and redefine skeletal muscle into a more cardiac-like structure.
- * Results showed that transplanted X-MET not only preserved heart function and increased survival rates in mice with chronic heart issues, but also reduced inflammation and collagen buildup, indicating its potential use in regenerative medicine.