Publications by authors named "Desire Soh"
is a medicinal plant widely studied due to its great phytochemical diversity, especially its acrinonic alkaloids, which have shown to be promising anticancer candidates. The aim of this work was to promote the isolation of acridonic alkaloids from fruits of and carried out absorption and fluorescence spectroscopy studies with calf thymus DNA and BSA. Five acridone alkaloids have been isolated, including the first description of 3-desmethoxy arborinine ().
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- This study explored Gymnema sylvestre, identifying twelve chemical compounds, including sterols, triterpenoids, and flavonoids, using various chromatography and spectroscopic techniques.
- The extract showed strong antioxidant activity, with significant free radical scavenging and reducing power, while compounds varied in efficacy.
- The antidiabetic effects were significant; the extract inhibited key enzymes related to carbohydrate digestion, and in silico studies indicated promising binding between compounds and these enzymes, suggesting potential for type 2 diabetes management.
Article Synopsis
- * A novel glucocerebroside called antroklaicerebroside was isolated, along with five previously known compounds, using advanced chromatographic techniques and characterized through NMR, MS, and IR spectroscopy.
- * Several fractions and isolated compounds were tested against chloroquine-resistant and susceptible strains of parasites, showing significant antiparasitic effects, with one compound exhibiting an impressive IC value that surpassed standard reference drugs.
Background: Hemsl. is a scandent shrub used in traditional medicine for the management of different ailments such as gout, female infertility, heart diseases, diabetes, and malaria. Pathophysiology of the diseases is generally associated with oxidative stress.
View Article and Find Full Text PDFTwo -kaurene diterpenoids, -15--acetyloxy-kaur-16-en-19-oic acid (xylopic acid) and -7-oxo-kaur-16-en-19-oic acid were isolated from the fruits of . Chemical manipulation of xylopic acid yielded -kaurane derivatives , , , and . Their structures were elucidated by spectroscopic analysis, including 1 D- and 2 D-NMR spectroscopies.
View Article and Find Full Text PDF3-O--D-glucopyranosyl gouanogenin A (), a new naturally occurring dammarane class of triterpene glucoside, has been isolated from the aerial parts of along with six known secondary metabolites . Their structure was elucidated through spectroscopic data including 1 D- and 2 D-NMR. The compounds and showed significant antioxidant potential in DPPH radical scavenging assay.
View Article and Find Full Text PDFTwo new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3-12). Structures of the new compounds were elucidated by extensive spectroscopic studies. Except compounds 11 and 12, all the other chemical compounds are newly reported from Leplaea genus.
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