Publications by authors named "Desire Bonci"
Article Synopsis
- The insulin IGF-1-PI3K-Akt signaling pathway may enhance heart function by affecting calcium handling through Akt, but the specific mechanisms were unclear.
- Akt has been found to regulate the density of L-type Ca(2+) channels (LTCC) by affecting the protein levels of Ca(v)alpha1, which is crucial for calcium flow in heart muscle cells.
- The phosphorylation of Ca(v)beta2 by Akt prevents the degradation of Ca(v)alpha1, leading to higher LTCC density and potentially improving calcium entry and heart contraction.
