Naltrexone and cyclazocine. A controlled treatment study.

The induction side effects of cyclazocine and naltrexone were compared in double-blind placebo-controlled studies involving 40 patients (20 for each drug). These studies were carried out with a twice-a-day dosage regimen. Naltrexone produced fewer side effects than cyclazocine.

Utility of d4-PGE2 as an internal standard to quantify endogenous levels of PGE1, PGE2, 19OH PGE1 and 19OH PGE2 in human seminal fluid by GC-MS-SIM.

Four prostaglandins-PGE1, PGE2, 19OH PGE1 and 19OH PGE2-were quantified in human seminal fluid by GC-MS-SIM using only the internal standard, d4-PGE2. Methods and calculations were developed to minimize errors inherent in using only one internal standard for quantifying four closely related prostaglandins. Preliminary data concerning the statistical significance of the difference found between PGE and 19OH PGE levels in fertile, azospermic and oligospermic men are reported.

11, 15, 19-trihydroxy-9-ketoprost-13-enoic acid and 11, 15, 19-trihydroxy-9-ketoprosta-5, 13-dienoic acid in human seminal fluid.

Two novel prostaglandins (PG) have been found in human seminal fluid which had been frozen immediately after collection. They were characterized by combined gas-liquid chromatography-mass spectrometry of various derivatives as 19-hydroxy prostaglandin E1 (11, 15, 19-trihydroxy-9-ketoprost-13-enoic acid) and 19-hydroxy prostaglandin E2 (11, 15, 19-trihydroxy-9-ketoprosta-5, 13-dienoic acid). They were present in three to five times the quantity of prostaglandins E1 and E2.

Prostaglandins in human seminal fluid: two novel compounds.

Human seminal fluid frozen immediately after ejaculation contains two novel prostaglandins. These are present in larger quantities than the previously reported prostaglandins. They are characterized by gas chromatography and mass spectrometry as 19-hydroxyprostaglandins E1 and E2.

Mass spectra of prostaglandins: II. Trimethylsilyl and alkyloxime-trimethylsilyl derivatives of prostaglandins B1 and B2.

The mass spectra of the trimethylsilyl ester trimethylsilyl ether derivatives of prostaglandins B1 and B2, and of theirO-ethyl andO-methyl oximes are reported and discussed. The high resolution spectra of these compounds are also considered. These spectra are compared with those of the correspondingd 9-trimethylsilyl derivatives and of the selectively labeled trimethylsilyl esterd 9-trimethylsilyl ethers.