Publications by Deshun Yang

Publications by authors named "Deshun Yang"

Curr Mol Med

May 2024

Osteoarthritis (OA) is a chronic joint disease marked by the breakdown of cartilage, and the anti-inflammatory compound Polyphyllin I (PPI) may help, though its mechanism in OA is not fully understood.
In experiments, PPI was shown to improve chondrocyte health by reducing cell death and inflammation induced by IL-1β, while also enhancing collagen II expression in a dose-dependent manner.
The beneficial effects of PPI were linked to the downregulation of TWIST1, a gene related to apoptosis and inflammation; overexpression of TWIST1 negated PPI's protective effects on chondrocytes.

J Neuroimmunol

October 2021

Excess activation of inflammatory microglia worsens spinal cord injury (SCI), and inhibiting the protein Arhgef3 can reduce this inflammation.
In laboratory tests and animal models, increased Arhgef3 levels were linked to heightened microglial activity and inflammatory responses.
Reducing Arhgef3 not only lowered inflammation and reactive oxygen species production after injury but also led to improved recovery and reduced secondary damage in mice, suggesting it may be a potential target for treating SCI.

Cell Tissue Bank

March 2022

NPC degeneration is a key factor in intervertebral disc diseases, and this study explores using autologous chondrocytes (CHs) that overexpress the sirt1 gene to improve NPC health.
The research shows that co-culturing NPCs with sirt1-overexpressed CHs leads to increased cell viability and reduced signs of degeneration, indicating that these CHs promote better NPC condition.
This approach could offer a novel treatment strategy for intervertebral disc degeneration by mitigating oxidative stress and inflammation in NPCs.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

October 2020

The study aimed to assess the effectiveness of the calcaneal plate bridge reconstruction for treating acetabular fractures using the modified Stoppa approach, analyzing data from 18 patients over a few years.
The patient demographics included 12 males and 6 females aged between 28 to 63, with most injuries caused by traffic accidents, and various types of fractures classified by the Letournel-Judet system.
Post-operative results showed a high satisfaction rate of 94.4% in reduction quality, with all fractures healing within an average of 3.4 months and no complications like internal fixator failure detected by the last follow-up.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

February 2017

The study aimed to evaluate the effectiveness of percutaneous kyphoplasty (PKP) using an improved injecting tube through a single puncture site for treating osteoporotic vertebral compression fractures.
During the research period, 60 cases were analyzed, with one group using a routine injecting tube and the other using an improved version, showing no significant differences in key preoperative metrics or complication rates.
Results indicated that while both methods improved postoperative outcomes like pain and vertebral height, the improved injecting tube offered better bone cement distribution, suggesting it could be a more effective option without increasing operation time or complication risks.