Rational Design of a Dual-Reactivity-Based Fluorescent Probe for Visualizing Intracellular HSNO.

Thionitrous acid (HSNO), the smallest S-nitrosothiol, is emerging as a potential key intermediate in cellular redox regulation linking two signaling molecules H S and NO. However, the chemical biology of HSNO remains poorly understood. A major hurdle is the lack of methods for selective detection of HSNO in biological systems.

A smartphone based device for the detection of sulfane sulfurs in biological systems.

Sulfane sulfur species are newly recognized signaling molecules that play physiological roles in many biological events. The development of new technologies for the detection of sulfane sulfurs is important. Point-of-care (POC) devices are in-field rapid and low-cost detectors that are more convenient to use than bulky and expensive standard instruments.

Strategies for the Design of Donors and Precursors of Reactive Sulfur Species.

Reactive sulfur species (RSS) play regulatory roles in biological systems. Many RSS are highly reactive and transient molecules, making their study difficult. RSS donors or precursors, which are used to specifically produce or deliver RSS, are useful research tools, as well as possible therapeutic agents.

Phosphonothioate-Based Hydrogen Sulfide Releasing Reagents: Chemistry and Biological Applications.

Hydrogen sulfide (HS) is a newly recognized gasotransmitter. Studies have demonstrated that the production of endogenous HS and the exogenous administration of HS can regulate many physiological and/or pathological processes. Therefore, HS releasing agents (also known as HS donors) are important research tools in advancing our understanding of the biology and clinical potential of HS.

Benzothiazole Sulfinate: A Sulfinic Acid Transfer Reagent under Oxidation-Free Conditions.

Sulfinic acids are commonly encountered intermediates found in natural product synthesis and medicinal chemistry. However, because of high reactivity, instability, and harsh reaction conditions, they are difficult to synthesize. Herein we have developed an oxidation-free method to produce sulfinic acids and sulfinate salts using 2-sulfinyl benzothiazole (BTS).