Efficacy of sorafenib combined with transcatheter hepatic arterial chemoembolization in treating intermediate-advanced hepatocellular carcinoma.

Purpose: To explore the efficacy and safety of sorafenib combined with transcatheter hepatic arterial chemoembolization (TACE) in the treatment of intermediate-advanced hepatocellular carcinoma (HCC).

Methods: A total of 132 intermediate-advanced HCC patients were divided into two groups, namely, control group (n=66, TACE) and Sorafenib group (n=66, TACE combined with sorafenib). Then, the clinical efficacy and incidence rate of adverse reactions were compared s.

Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese.

Background: High-density lipoprotein (HDL) is a major plasma lipoprotein directly associated with cholesterol metabolism. The ATP binding cassette transporter 1 gene (ABCA1) is one of the major genes modulating plasma levels of HDL-cholesterol (HDL-C). Rare alleles of ABCA1 associated with extreme HDL-C concentrations have not been previously investigated in the Chinese.