[Processes of absorption and utilization of glucose in newborn infants with intrauterine hypotrophy].

Overall 75 neonates with intrauterine hypotrophy (IH) and 19 healthy children were examined for glucose absorption and utilization according to the glucose tolerance test data. IH neonates were revealed to have and increase of glucose absorption and retardation of its utilization. The high blood glucose concentrations seen 2 hours after the test support functional insufficiency of the pancreas in IH.

[Effect of chronic intrauterine hypoxia on purine compound metabolism in the erythrocytes of newborn infants in the early neonatal period].

The content of purine compounds in red blood cells was measured and compared in 21 neonates with a history of chronic intrauterine hypoxia, depending on the condition at birth and the early period of adaptation. The content of purine compounds in whole blood was measured at the moment of birth and on days 1, 3 and 5 of life. It has been disclosed that the pattern of purine metabolism abnormality in funic red blood cells makes it possible to predict the course of the early period of adaptation.

[Study of the formation of intestinal microflora in newborn infants staying with or separated from their mothers].

In children of the first month of life, the formation of normal intestinal microflora was studied depending on whether they stayed with mothers or alone in the maternity home. Thirty healthy neonates born to young healthy mothers with a history of a favourable course of pregnancy which progressed to the delivery via the natural maternal passages were examined. Intestinal microbiocenosis in the newborn turned out more physiological provided they were placed at the "mother-child" department as compared to that when the newborn stayed alone.

[Indicators of lipid peroxidation and the level of essential microelements in healthy newborn infants and in those with a history of intrauterine hypotrophy].

The authors describe the results of studying lipid peroxidation, total antioxidant activity of plasma and the content of essential trace elements (iron, copper, zinc and selenium) in 35 healthy neonates and in 32 with intrauterine hypotrophy, grades I-III, at birth and the course of the early neonatal period. It has been found that in the neonates with a history of intrauterine hypotrophy, activation of lipid peroxidation resulted in the decrease of plasma antioxidant activity and in the changes of the concentration of essential trace elements.

[Contents of bioelements in blood of newborn infants with a history of chronic intrauterine hypoxia].

Emission analysis with the use of induced plasma was employed to measure the content of 9 bioelements (potassium, sodium, calcium, magnesium, phosphorus, iron, copper, zinc and selenium) in the blood serum of 82 neonates with a history of chronic intrauterine hypoxia and in 19 normal children at birth and in the course of early adaptation. It has been shown that the content of bioelements in the blood of normal neonates was marked by a number of characteristic features reflecting to a considerable degree the processes of metabolic adaptation of the children to the intrauterine life. The neonates with a history of hypoxia demonstrated the unbalance of bioelements most pronounced by day 3 of life.

[Nonspecific resistance of the body and predisposition to acute leukemia in children].

An analysis of 422 Moscow hospital records of children suffering from acute leukemia during the period from 1959 and continuing through to 1979 showed that the proportion of those with morphologically "average" weight and body length values at birth, was significantly lower in the group with leukemia, than in the control group of healthy children. Genetic structure of leukemic and healthy children was found to be significantly different by phenotypic combinations of 2 loci (ABO and Rhesus). The distribution of children for their age at the beginning of the disease was studied.