[Evaluation of the potential cardiotoxicity of propranolol-lithium gluconate association (author's transl)].

The association B blocking agent-lithium salt is used for the therapy of some severe hyperthyroidism with cardiotoxicosis. Separately, both drugs depress intracardiac conduction. However by recording the potentials of the His bundle in anesthetized dogs, a potential cardiotoxicity of this association is unlikely since sinusal automaticity alone is importantly slowed.

Inhibition by idrocilamide of the disposition of caffeine.

The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.

Macromolecular and histological studies of new tissue formation in velour vascular prostheses.

The nature and characteristics of the tissue which develops on the inner surfaces of vascular arterial prostheses have been investigated by means of histological and biochemical criteria. Velour prosthetic tubes were implanted as aortic segmental replacements in the dog. On the 60th postoperative day, a neointimal layer of collagen covered with flattened endothelial-like cells was noted.

Another look at the Sparks-Mandril arterial graft precursor for vascular repair. - Pathology by scanning electron microscopy.

The Sparks-Mandril blood vessel precursor system, an autogenous tissue growth-promoting device, in spite of its ingenuity and its surgical elegance, has received only limited usage. At technique for peripheral blood vessels by several authors. In the latter period, this laboratory also undertook similar work.

Revascularization of the spinal cord by micro-anastomoses in dogs.

The severity of ischemic lesions in the spinal cord justifies attempts at its surgical revascularization. The experiments consisted of: (1) creating devascularization of the conus medullaris by ligation of all the lumbo-sacral collaterals of the aorta, and (2) revascularizing the lumbo-sacral rachidian circulation by performing an end-to-side anastomosis between the caudal mesenteric artery and the 5th left lumbar artery (from which in the dog the Adamkiewicz artery generally arises). After two-months, the patency rate of the 20 cases was 85%.

[Should phlebitis of the limbs be treated surgically (author's transl)].

Controversy persists between partisans of medical treatment and partisans of wide surgical indications. In iliocaval phlebitis, the authors defend surgery insofar as the operation is restorative, whilst remaining "reasoned" in terms of the lesions and the numerous factors involved. Experience of 90 cases of phlebitis treated over the past two years has shown that restoration may be obtained and maintained in more than half the number of cases and that prophylactic partial venous occlusion proved necessary in only 30% of cases.

Study of thioridazine cardiotoxic effects by means of His bundle activity recording.

The effect of thioridazine on sinusal automaticity, myocardial excitability and auriculoventricular conduction have been studied in dogs by measuring the spontaneous heart rate, the effective refractory period of the atrial contractile tissue, the time of auriculonodal and infrahisian conduction. Chloralose anaesthetized dogs were administered 10 mg/kg thioridazine hydrochloride via intravenous route. While sinusal automaticity was not altered, conduction times were prolonged in the suprahisian and mainly the infrahisian part and the atrial refractory period increased.

[Effect of levomepromazine on atrioventricular conduction tissue (author's transl)].

The effect of levomepromazine on sinusal automaticity, myocardial excitability and auriculoventricular conduction have been studied in dogs by measuring the spontaneous heart rate, the effective refractory period of the conduction system, the time of auriculonodal and infrahisian conduction. Chloralose-anaesthetized dogs were administered 5 mg/kg levomepromazine via IV route and 10 mg/kg one hour later. While sinusal automaticity is never altered, the other parameters studied were modified only when high doses were used.

[Grave obstetrical phlebitis. Physiopathology, diagnosis and treatment (6 case histories) (author's transl)].

The authors detail their concepts of the physiopathology, the diagnostic methods and the treatments of grave puerperal phlebitis, having seen six cases in their two departments recently. They consist of 5 cases of iliofemoral thrombosis, 2 of whom were diagnosed during their pregnancies and 3 others whom were diagnosed after delivery. One of these died of pulmonary embolus: and there was one case of thrombosis of the right ovarian vein during post-partum.

Mechanism of glycoconjugates biosynthesis in the vascular wall with external circular constraint.

Extrinsic local constraints, realised on dogs aorta are responsible for parietal lesions in the form of thickening of the arterial wall. Histological changes in the intima and media are characteristic of processes of degeneration destruction and cellular regeneration, superposed on sub-endothelial proliferation accompained by partial or total destruction of endothelial cells in the intimal layer. In addition to histological changes, there were perturbation in enzymatic activities of glycosyltransferases responsible for macromolecular constructions in the intima.

Microvascular bypass grafts. Experimental study of pathologic changes in arterial and venous grafts.

Experimental autogenous grafts were made on adult Wistar rats using microvascular techniques. 3 months postoperatively, the grafts were controlled by angiography and by histopathological examination. We obtained a total patency rate of 52.

[Mechanism of biosynthesis of glycoconjugates at the level of the arterial walls after contact with alloplastic materials (author's transl)].

The object of this work was to show that here exists after contact with foreign substances, a construction of protein, glycoprotein and mucopolysaccharide macromolecules at the level of the intima of the great vessels. Woven Dacron prostheses have been implanted in the arterial circulation of dogs (on the subrenal abdominal aorta). After removal of vascular segments, we carried out a subcellular fractioning, controlled and studied in an acellular system in vitro the activity of the glycosyltransferases implied in the construction of glycan chains of glyccproteins.

Time dependent modifications in arterial flow in a transplanted pulmonary lobe.

Study of pulmonary arterial flow in the transplanted lung by means of an implanted ultrasonic flowmeter enables us: 1. To confirm results obtained by other methods (De Bono,8 Strider14 and Strandberg18): without specific treatment, rejection of graft causes increased peripheral resistances and the pulmonary arterial flow decreases progressively. 2.