Publications by Deschana L Washington

Publications by authors named "Deschana L Washington"

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Dual targeting of KDM1A and antioxidants is an effective anticancer strategy.

Shaila Mudambi Megan E Fitzgerald Deschana L Washington Paula J Pera Wendy J Huss

bioRxiv

June 2024

Lysine Specific Demethylase 1 (KDM1A / LSD1) regulates mitochondrial respiration and stabilizes HIF-1A (hypoxia-inducible factor 1A). HIF-1A modulates reactive oxygen species (ROS) levels by increasing cellular glucose uptake, glycolysis, and endogenous antioxidants. The role of KDM1A in cellular ROS response has not previously been described.

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