Publications by authors named "Descamps V"
Most of the world's adult population is latently infected by the BK polyomavirus. It causes asymptomatic infection in healthy individuals but emerged as a threat to kidney transplant recipients because of virus-associated nephropathy caused by immunosuppressive therapy. In these conditions, when a functional cellular response is impaired by immunosuppression, neutralizing antibodies may play a major role because they can directly prevent infection of target cells, independently of cell-mediated immunity, by binding to the viral particles.
View Article and Find Full Text PDFApalutamide is a selective androgen receptor signalling inhibitor that is used in the treatment of prostate cancer. Skin rash is one of the most common adverse events with apalutamide. Although the majority of rash events are grade 1 and 2, the appearance of skin rash during treatment can lead to dose reduction, a pause in treatment or even treatment discontinuation, especially if patients present late when the rash has become severe.
View Article and Find Full Text PDFArticle Synopsis
- The BK polyomavirus (BKPyV) typically causes no symptoms in healthy adults but can lead to serious health issues like nephropathies and hemorrhagic cystitis in immunocompromised patients, particularly those with organ transplants.
- Recent research shows that BKPyV can use extracellular vesicles to move between cells without causing cell damage, which is a unique strategy for virus entry and exit.
- The study looked into whether BKPyV uses certain viral protein domains to assist in this vesicle trafficking, finding that while a specific domain in the VP1 protein doesn't aid in vesicle association, it's critical for proper viral particle assembly.
Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic. Concomitant replication is rare and potential competition between the infections has been described.
View Article and Find Full Text PDFBackground/objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus's impact on the graft outcome.
Methods: In a 7-year study, we screened more than 430 kidney transplant recipients and analyzed the time course and virological characteristics of BKPyV replication.
Results: Urinary viral replication was observed in 116 (27%) of the 430 patients, and 90 of the 116 (78%) had viral DNAemia.
Article Synopsis
- * A study of 120 patients showed that 36% achieved complete cutaneous remission after one year, with oral corticosteroids and a hydroxychloroquine/topical steroids combo yielding the best results.
- * The findings suggest using hydroxychloroquine and topical steroids as the best first-line treatment due to the negative side effects associated with systemic corticosteroids, with lupus pernio being a predictor of poor response.
Background: BK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new tools are required to enhance the biological monitoring of the infection. Viral microRNAs are promising new biomarkers, but the performance of RT-qPCR methods limits the clinical application and the validation of a standard method for quantification.
View Article and Find Full Text PDFHIV evolution and variability around the world requires special monitoring of the viral strains in infected people. High-throughput HIV sequencing and drug resistance testing techniques have become routinely available over the last few years. We conducted a study to assess the new CE-marked ABL NGS HIV genotyping assay on an Illumina® platform, to compare the results (the detection of resistance associated mutations (RAMs) detected in the three main targets: reverse transcriptase, protease, and integrase) with those produced by three Sanger-based assays, and to compare the assays' respective costs.
View Article and Find Full Text PDFBackground: Several biologics (Bx) and targeted synthetic drugs (TSD) exist to treat T2 diseases, including chronic spontaneous urticaria (CSU), severe asthma (SA), chronic rhinosinusitis with nasal polyposis (CRSwNP) or atopic dermatitis (AD).
Objective: To identify patients treated with Bx/TSD from a dynamic dispensing database using an algorithm-based methodology.
Methods: We used the LRx database (Lifelink Treatment dynamics, IQVIA) which covers nearly 45% of the French retail pharmacies.
Importance: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment.
Objective: To reach an international, Delphi-based multinational expert consensus on the diagnostic workup, severity assessment, and treatment of patients with DRESS.
Data regarding elderly melanoma patients treated with anti-PD-1 or anti-CTLA-4 antibodies are in favor of tolerability outcomes that are similar to those of younger counterparts. However, there are very few studies focusing on elderly patients receiving nivolumab combined with ipilimumab (NIVO + IPI). Here, we ask what are the current prescribing patterns of NIVO + IPI in the very elderly population and analyze the tolerance profile.
View Article and Find Full Text PDFBackground: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe adverse event (mortality of 10%). Its pathophysiology involves herpesviruses, particularly HHV-6, but the exact mechanisms are still poorly understood.
Objective: To describe severe cases of DRESS and especially their association with herpesvirus reactivation.
Article Synopsis
- - The study analyzed severe cases of crusted and profuse scabies from 95 inpatients across 22 French hospitals from 2009 to 2015, highlighting a higher prevalence in elderly individuals living in institutions.
- - Many patients had a history of misdiagnosis, with 43% initially diagnosed with conditions like eczema or psoriasis, and the average time to identify severe scabies was about 3 months despite prior treatments.
- - The research found significant variability in diagnosis and treatment practices, with most patients having comorbidities, stressing the need for standardized approaches in managing severe scabies cases.
Skin reactions are well described complications of tattooing, usually provoked by red inks. Chemical characterizations of these inks are usually based on limited subjects and techniques. This study aimed to determine the organic and inorganic composition of inks using X-ray fluorescence spectroscopy (XRF), X-ray absorption spectroscopy (XANES) and Raman spectroscopy, in a cohort of patients with cutaneous hypersensitivity reactions to tattoo.
View Article and Find Full Text PDFSkin histology of papules and pustules from 5 men having sex with men with mpox infection showed viral intracytoplasmic cytopathic changes, interface dermatitis, marked inflammatory dermic infiltrate including superficial neutrophils and perivascular and periadnexal deep lymphocytes. Histologic description of mpox lesions improves our understanding about clinical presentations and may have some therapeutic implications.
View Article and Find Full Text PDFIntroduction: Despite the existence of multiple assessment scores for psoriasis severity, skin disease with limited skin lesions but significant impairment of quality of life can be difficult to classify, leading to under- or overtreatment. Our objective was to obtain consensus on clinical criteria to classify psoriasis severity in French clinical practice, with a focus on moderate disease, using a modified Delphi method.
Methods: A steering committee (SC) formulated a 22-item questionnaire to classify moderate psoriasis.