RF power saving system for smart homes.

In this work the investigation results of harvesting the RF energy of a 2.4 GHz Wi-Fi signal for supply of smart home leak sensors network are presented. The collected RF energy has been used as an additional source to power the sensors.

The link between yeast cell wall porosity and plasma membrane permeability after PEF treatment.

An investigation of the yeast cell resealing process was performed by studying the absorption of the tetraphenylphosphonium (TPP) ion by the yeast Saccharomyces cerevisiae. It was shown that the main barrier for the uptake of such TPP ions is the cell wall. An increased rate of TPP absorption after treatment of such cells with a pulsed electric field (PEF) was observed only in intact cells, but not in spheroplasts.

The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation.

Platelet activating factor (PAF-acether) is a potential mediator of asthma and inflammation. Recently, the suggestion was made that inhibition of PAF-acether by disodium cromoglycate (DSCG) might be partly responsible for the effectiveness of DSCG in asthma. We have extended these studies and examined the effects of antiallergic and bronchodilator drugs on PAF-acether induced bronchospasm after i.

Bronchodilating activity of forskolin in vitro and in vivo.

The effect of forskolin, a receptor-independent adenylate cyclase activator on acetylcholine (ACh)-, histamine- and leukotriene D4 (LTD4)-induced contractions in isolated tracheal spirals was investigated. Forskolin reduced the contraction due to these agonists (IC50S: ACh 5.8 X 10(-6) M; histamine 4 X 10(-7) M; LTD4 3.

The comparative bronchodilator properties of alkyl quaternary salts of promethazine.

Several salts of thiazinamium, a quaternary analogue of promethazine, administered by aerosol, possessed equipotent anticholinergic activity in anesthetized guinea pigs but the duration of this effect differed somewhat. N-Butyl substitution in the side chain, but not the corresponding ethyl or n-propyl substitutions, reduced the aerosol anticholinergic potency and duration. There was also a tendency for a corresponding reduction in antihistaminic activity with different alkyl substitutions and for a greatly reduced duration of this effect.

Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.

Antihistamine-resistant anaphylactic bronchospasm in guinea pigs is increased with increasing doses of antigen (ovalbumin, OA) challenge. This was observed in passively and actively sensitized animals, and by both i.v.

Bronchodilator and antiallergic effects of thiazinamium chloride in guinea pigs, rats, cats and dogs.

This study characterized the in vivo pulmonary pharmacology of thiazinamium chloride administered largely by the aerosol route in different animal species. The compound has greater anticholinergic but weaker antihistaminic activity than promethazine, the parent compound. It was less potent than atropine or ipratropium as an anticholinergic and had a shorter duration of action, but unlike these compounds it had long-lasting antihistaminic activity.

Ascaris-induced allergic asthma in the conscious dog: a model for the pharmacologic modulation of immediate type hypersensitivity.

A noninvasive method has been described for producing and assessing Ascaris-induced bronchospasm in the conscious dog and the bronchial responsiveness of a colony of Ascaris-sensitive dogs has been examined over a 2 year period. Both individual and dog-to-dog variation are apparent from the study but the results differ from those of equivalent studies performed by others using anesthetized dogs in that sudden death is not observed. Furthermore, the responses to antigen are not influenced by anesthesia, a procedure that suppresses airway reactivity and pulmonary reflexes.

The pharmacologic profile of wy-41,195, a new orally effective antiallergic agent.

[2-Cyano-3-(methylamino)phenylamino]oxoacetic acid, sodium salt (Wy-41,195) was found to be a potent oral inhibitor (viz., ED50, 0.3 mg/kg) of IgE-mediated release in the rat passive cutaneous anaphylaxis (PCA) model and was very effective by the aerosol and oral route in the rat passive lung anaphylaxis model.

Immunopharmacologic properties of WY-16, 922, a new orally effective antiallergic agent.

In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 effectively inhibited reaginic-mediated immunologic reactions in the skin, lungs and mast cell. It was found to be devoid of immunosuppressant, antimediator, anti-inflammatory, steroid or bronchodilator properties as well as acute toxicity. Although the mechanism of action of Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner similar to that described for disodium cromoglycate.

Immunopharmacologic properties of WY-16,922, a new orally effective antiallergic agent.

In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 effectively inhibited reaginic-mediated immunologic reactions in the skin, longs and mast cell. It was found to be devoid of immunosuppressant, antimediator, anti-inflammatory, steroid or bronchodilator properties as well as acute toxicity. Although the mechanism of action Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner similar to that described for disodium cromoglycate.

Actions of prostaglandins on the respiratory tract of animals.

Experimental data now strongly suggest that the PGs, by nature of their natural local occurrence and destruction, powerful effects on, and release from lung tissue are important in regulating both pulmonary homeostasis and dysfunction. Laboratory studies on their activity, potency, duration, preferred route of administration, mechanism and possible antiallergic effects, have been largely substantiated in humans. Structure activity studies on a large number of congeners of PGE, PGF, and PGA emphasize the critical importance of stereochemistry and various substituent groups on biologic activity in the lung.