Dosage dependency of intravitreal triamcinolone acetonide as treatment for diabetic macular oedema.

Aim: To evaluate the effect of different doses of intravitreal triamcinolone acetonide on diffuse diabetic macular oedema.

Methods: The prospective, randomised, double masked, clinical interventional study included 27 eyes (27 patients) with diffuse diabetic macular oedema. They were randomly divided into three study groups receiving an intravitreal injection of filtered triamcinolone acetonide of about 2 mg (n = 8 eyes), 5 mg (n = 10), or 13 mg (n = 9), respectively.

Triamcinolone acetonide concentration after filtration of the solvent agent.

Purpose: To determine the amount of triamcinolone acetonide and the preservative benzyl alcohol after filtration.

Design: Laboratory investigation.

Methods: The probes were prepared by two different hospital pharmacies.

[Familial uveitis. Forms and incidence in patients at the University Eye Hospital Tubingen].

Objective: A familial accumulation in some forms of uveitis has rarely been described. The objective of this study was to identify such cases and to examine both clinical course and similarities in the HLA-pattern.

Methods: From 1993 to 2000 all new uveitis patients, who were examined in the uveitis clinic of the University Eye Hospital Tuebingen, were asked about a positive family history.

Effect of photorefractive keratectomy and laser in situ keratomileusis in high myopia on logMAR visual acuity and contrast sensitivity.

Purpose: To compare effect of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) on contrast sensitivity (CS) and best corrected visual acuity (BCVA) in high myopia.

Methods: 38 myopes (PRK) and 31 patients (LASIK) were examined before and 1, 3, 6, and 12 months postoperatively. Mean preoperative spherical equivalent was -8.

[Successful topical cyclosporin A in the therapy of progressive vascularising keratitis in keratitis-ichthyosis-deafness (KID) syndrome (Senter syndrome)].

Background: The keratitis-ichthyosis-deafness (KID) syndrome (Senter Syndrome) and its major criteria erythrokeratodermia, neuro-sensoric deafness and vascularising keratitis were defined in 1981. Several cases have been described since 1915, but up to now no causal therapy of this disease with sporadic occurrence has been found. Clinical experience using systemic Cyclosporin A (CsA) in the dermatological therapy of the KID syndrome differs.

[Measurement of intraocular pressure using the Tono-Pen in comparison with Goldmann applanation tonometry - a clinical study in 100 eyes].

Background: In clinical practice ophthalmologists often need a tonometer which is independent of a slit lamp. Such a hand-held device is the Tono-Pen. We compared the precision of two equal Tono-Pens with Goldmann applanation tonometry.

Efficacy and safety of contact transscleral diode laser cyclophotocoagulation for advanced glaucoma.

Background: This prospective study was conducted to evaluate the efficacy and safety of transscleral diode laser cyclophotocoagulation in refractory, advanced glaucoma.

Patients And Methods: One hundred eyes of 100 patients with advanced glaucoma refractory to medical treatment were consecutively treated by transscleral diode laser cyclophotocoagulation. Success was defined as a final intraocular pressure between 5 and 21 mm Hg in eyes with a visual acuity of more than hard movements, relief of pain in eyes with a visual acuity of hand movements or less including blind eyes, and reduction of carbonic anhydrase inhibitor use in all eyes.

Subconjunctival anesthesia in contact diode laser cyclophotocoagulation.

Background: Retro- or peribulbar anesthesia are the standard procedures for cyclodestructive surgery. Because these methods of anesthesia may further compromise optic nerve function, especially in advanced glaucoma, subconjunctival anesthesia was evaluated as an alternative procedure in contact diode laser cyclophotocoagulation (CPC).

Patients And Methods: A prospective study concerning diode laser CPC in advanced glaucoma was started using subconjunctival anesthesia with 2% mepivacaine.

Transscleral diode laser cyclophotocoagulation for the treatment of refractory glaucoma secondary to inflammatory eye diseases.

Background: Inflammatory glaucoma is still a diagnostic and therapeutic dilemma and surgical intervention is always associated with a high risk of failure or reactivation of the inflammatory disease. In this study we prospectively examined the value of transscleral diode laser cyclophotocoagulation (TDLC) for the treatment of refractory inflammatory glaucoma.

Methods: 22 eyes of 20 consecutive patients with inflammatory, medically uncontrollable, glaucoma secondary to chronic uveitis/trabeculitis (n = 18), chemical injury (n = 2), episcleritis (n = 1), and necrotising scleritis with inflammation (n = 1) were treated by TDLC.

[Cyclocryocoagulation in treatment of therapy refractory glaucoma: a retrospective analysis of 185 cryocoagulation procedures].

Background: For several years it has been discussed whether cyclocryotherapy is still an up-to-date treatment of resistant inadequately controlled glaucoma. This retrospective study investigates the clinical aspects of 185 cyclocryotherapies between 1988 and 1997.

Patients And Methods: At the University Eye Clinic of Tübingen, 114 patients received in 119 eyes (64.

[Impairment of mesopic vision following photorefractive keratectomy of myopia].

Purpose: Halos, glare disability and problems during night driving are significant side effects of photorefractive keratectomy, caused by increasing optical aberrations under reduced conditions of luminiscence. In a previously performed retrospective study an impairment of mesopic vision in most of the investigated eyes was found. To prove these results, a prospective study was conducted.

Holmium:YAG thermokeratoplasty: treatment parameters for astigmatism induction based upon spherical enucleated human eyes.

Background: The refractive outcome of thermokeratoplasty for astigmatism correction depends upon the optical zone diameter (OZD) and coagulation angle (CA; distance between two coagulation spots around the flat meridian).

Methods: Astigmatism was induced in 36 spherical human eye-bank eyes (Ho:YAG laser, 15 Hz, 20 mJ/pulse, 25 pulses per coagulation spot) with different OZDs and CAs. Thirty eyes received free-hand laser application (marked positions).

Mesopic vision in myopia corrected by photorefractive keratectomy, soft contact lenses, and spectacles.

Purpose: To evaluate contrast vision and glare sensitivity under mesopic conditions in eyes having uncomplicated excimer laser photorefractive keratectomy (PRK) for myopia and in eyes corrected by disposable soft contact lenses, soft contact lenses, and spectacles.

Setting: Division of Experimental Ophthalmic Surgery, University of Tübingen, Germany.

Methods: The Mesoptometer II test was used to evaluate mesopic vision (glare sensitivity and contrast vision) in 28 eyes of 14 patients wearing disposable soft contact lenses, 20 eyes of 10 patients wearing soft contact lenses, 39 eyes of 20 patients wearing spectacles, 30 eyes of 15 emmetropic patients, and 33 eyes of 22 patients after PRK with 5.

[Accidental retinectomy in block excision for cystic epithelial ingrowth].

A 3.5-year-old girl suffered from a penetrating injury of the left eye. One and a half years later epithelial ingrowth was detected.

Complications of myopic photorefractive keratectomy with the excimer laser.

Background: Although many thousands of myopic eyes have been operated on by excimer laser photorefractive keratectomy (PRK), the safety of this procedure is still a concern.

Methods: The results and complications of PRK have been studied for up to 2 years in a prospective trial including 193 eyes in 146 patients. In addition, specific complications of PRK are described that occurred in patients outside the prospective study.

Aspheric photorefractive keratectomy with excimer laser.

Background: Increased spherical aberration of the cornea is a common finding after excimer laser keratorefractive keratectomy. The shape of the paracentral cornea is probably related to the incidence of side effects like glare and halos at night depending on ablation zone size and pupil diameter. Aspheric curvature changes of the paracentral cornea at the edge of the ablation may decrease those side effects.

Repeated excimer laser treatment after photorefractive keratectomy.

Scarring or undercorrection occurs in a small percentage of patients after myopic photorefractive keratectomy. Scarring occurred in 1.8% of 298 patients with a baseline myopia of 6.