Publications by authors named "Derrick Tambe Ayuk Ngwese"
Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study.
Front Med (Lausanne)
September 2024
Background: The elevated rate of AIDS-related mortality in Sub-Saharan Africa among adolescents living with HIV (ALHIV) is influenced by various factors, notably immunosuppression, within a framework of limited therapeutic alternatives. We aimed to enhance the management of pediatric HIV by assessing the immune response and associated factors in perinatally-infected ALHIV on antiretroviral therapy (ART) in Cameroon.
Methods: A cohort study was conducted from 2018-2020 among 271 ART-experienced ALHIV in Cameroon.
XBB.1, BQ1.1 and atypical BA.4.6/XBB.1 recombinants predominate current SARS-CoV-2 Wavelets with flu-like symptoms in Cameroon: A snapshot from genomic surveillance.
PLOS Glob Public Health
May 2024
As of December 2022, Cameroon had observed a slight resurgence of COVID-19, raising concerns on genomic surveillance of related-SARS-CoV-2 variants under circulation. Following a laboratory-based survey, positive SARS-CoV-2 samples detected from December-2022 through March-2023 were processed for targeted sequencing at the Chantal BIYA International Reference Centre (CIRCB) in Yaoundé-Cameroon. From all positive cases detected, 13 were successfully sequenced (mean age 34 years, 70% female); the majority of the cases were unvaccinated (70%, 9/13) and symptomatic (92%, 12/13); all with flu-like symptoms (100%, 12/12).
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- - WHO suggests COVID-19 antigen rapid tests should have at least 80% sensitivity and 97% specificity, and this study evaluates the INDICAID™ Ag-RDT against RT-PCR as the gold standard, focusing on Omicron variants.
- - The study involved 565 nasopharyngeal swabs, revealing that for samples with higher viral loads (CT < 25), INDICAID™ displayed 100% sensitivity, while still maintaining high specificity and good predictive values.
- - The findings indicate that INDICAID™ Ag-RDT is highly effective for diagnosing COVID-19 in individuals with high viral loads, making it a practical tool for community-level prevention amidst the prevalence of Omicron subvariants.
Article Synopsis
- There has been an increase in Monkeypox (Mpox) cases globally, prompting a study on healthcare workers' understanding of its transmission, prevention, and response in Cameroon.
- An online survey was conducted with 342 healthcare workers, revealing that while over 90% were aware of Mpox, only 12.9% had excellent knowledge and 42.1% had good knowledge of the disease.
- The findings suggest a need for capacity-building programs to enhance healthcare workers' education on Mpox to ensure effective response to this and similar emerging diseases.
Allele-Specific Polymerase Chain Reaction (ASPCR) is an affordable point-mutation assay whose validation could improve the detection of HIV-1 drug resistance mutations (DRMs) in resource-limited settings (RLS). We assessed the performance of ASPCR onforty-four non-B HIV-1 plasma samples from patients who were ARV treated in failure in N'Djamena-Chad. Viral RNA was reverse-transcribed and amplified using LightCycler® FastStart DNA MasterPLUS SYBR Green I.
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