Publications by authors named "Derrick K Rollins"

The ability to accurately develop subject-specific, input causation models, for blood glucose concentration (BGC) for large input sets can have a significant impact on tightening control for insulin dependent diabetes. More specifically, for Type 1 diabetics (T1Ds), it can lead to an effective artificial pancreas (i.e.

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Many patients with diabetes experience high variability in glucose concentrations that includes prolonged hyperglycemia or hypoglycemia. Models predicting a subject's future glucose concentrations can be used for preventing such conditions by providing early alarms. This paper presents a time-series model that captures dynamical changes in the glucose metabolism.

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Background: Microarray data sets provide relative expression levels for thousands of genes for a small number, in comparison, of different experimental conditions called assays. Data mining techniques are used to extract specific information of genes as they relate to the assays. The multivariate statistical technique of principal component analysis (PCA) has proven useful in providing effective data mining methods.

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Article Synopsis
  • - The article presents a new PCA-based method aimed at identifying assay-specific gene signatures in functional genomic studies, overcoming limitations of existing techniques.
  • - This method uniquely incorporates gene contribution by combining loading and expression levels and utilizes two innovative types of assay-specific contribution plots to visualize gene importance and identify outliers.
  • - The proposed method effectively analyzes the entire dataset to finalize gene signatures, minimizing the risk of omitting significant genes due to inadequate initial screenings, with its effectiveness demonstrated through simulations and real DNA microarray datasets.
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