Publications by authors named "Derk F M Avenarius"
Article Synopsis
- - The study aimed to compare two MRI sequences—T2 Dixon fat-only and T1-weighted—in assessing high signal areas in bone marrow of healthy children and adolescents, focusing on optimizing scan time.
- - Data from 196 participants aged 6 to 19 years were analyzed, and a scoring system classified findings as "minor" or "major," with high agreement (94.6%) between sequences for the majority of assessed areas.
- - The findings suggest that T2 Dixon fat-only can effectively replace T1-weighted sequences for kids over nine, leading to reduced MRI scan durations.
Article Synopsis
- The study investigates high signal areas on T2 weighted MRI images of the bone marrow in the axial skeleton of healthy children and adolescents aged 5-19 years.
- A total of 196 participants were examined, leading to the identification of 415 areas of increased signal, with 75 categorized as major findings, particularly in the pelvis.
- The findings highlighted the prevalence of non-specific bone marrow hyperintensities, emphasizing the need for awareness to differentiate these from actual skeletal diseases in children.
Article Synopsis
- The study aimed to analyze bone marrow appearances in the appendicular skeleton of healthy children and adolescents using whole-body MRI with fat suppression.
- It involved 196 participants aged 5-19 years, where bone marrow signals were graded for intensity and extension using a newly created scoring system.
- Results showed that over half of the individuals displayed significant focal areas of high signal intensity, primarily in the hands, humerus, feet, and knees, highlighting the need for careful interpretation of MRI findings in this population.
Article Synopsis
- Manual evaluation of bone marrow signals is time-consuming and requires strict standardization for accuracy.
- The study aimed to explore the use of deep learning to automate the segmentation of bone marrow signals in young individuals using knee MRI images from a multi-centered study.
- Results indicated that the deep-learning model performed well for lower intensity signals but struggled with higher intensity signals, suggesting the need for more extensive training datasets and cross-institutional validation to enhance accuracy.
Article Synopsis
- Wrist involvement in juvenile idiopathic arthritis (JIA) affects approximately 25% of patients at diagnosis, rising to 40% after 5 years.
- The imaging characteristics for JIA in children differ significantly from those in adult rheumatoid arthritis, highlighting the need for a specialized approach for assessment.
- This review article offers an update on the current imaging practices for wrist involvement in JIA, emphasizing evidence-based methodologies.
Objective: The presence of findings at wrist MRI that may mimic disease is a diagnostic problem. The purpose of this study is to examine the occurrence of bone marrow changes resembling edema, joint fluid, and ganglion cysts over time, in a cohort of healthy children.
Materials And Methods: Seventy-four of 89 healthy children included in a study of normal MRI findings of the wrists were reexamined after a period of 4 years, using the same 1.
The many shades of enhancement: timing of post-gadolinium images strongly influences the scoring of juvenile idiopathic arthritis wrist involvement on MRI.
Pediatr Radiol
October 2016
Background: Potential long-term side effects of treatment for juvenile idiopathic arthritis are concerning. This has necessitated accurate tools, such as MRI, to monitor treatment response and allow for personalized therapy.
Objective: To examine the extent to which timing of post-contrast MR images influences the scoring of inflammatory change in the wrist in children with juvenile idiopathic arthritis.
Article Synopsis
- Many healthy children show carpal depressions on MRI, which can be mistaken for signs of juvenile idiopathic arthritis in other populations.
- A study re-scanned 74 healthy children to track these depressions over time and assessed the presence of cartilage over the depressions as a way to differentiate between normal variants and actual erosions.
- Results indicated that while the number of depressions increased with age, most locations remained the same, and a significant portion was covered by cartilage, suggesting that not all bony changes indicate pathology during normal growth.
In Alpha-mannosidosis (MIM 248500) the patients accumulate mainly unbranched oligosaccharide chains in the lysosomes in all body tissues, including the brain. With ensuing therapeutic modalities in man (BMT and ERT) non-invasive methods of monitoring the effect of treatment are needed. Paramount is the possible effect of the treatment on the brain, since this organ is regarded as difficult to reach because of the blood-brain barrier.
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