Publications by authors named "Derieux S"
Article Synopsis
- The study evaluates the outcomes of delayed coloanal anastomosis (DCAA), focusing on its use as both a primary procedure and as a salvage after failed surgery.
- Among 564 patients, complications occurred at similar rates for both types of DCAA, but anastomotic leakage was more common in salvage DCAA cases.
- DCAA successfully preserved bowel continuity for 74% of patients after three years, with 75% of those not initially having a stoma avoiding it entirely by the last follow-up.
Background: Perioperative chemotherapy is the gold standard in gastric cancer management. The prognostic significance of pathological response has been investigated in many malignancies, using Tumor Regression Grade (TRG). Its prognostic value in gastric cancer remains poorly known.
View Article and Find Full Text PDFGastric cancer (GC) is a highly heterogeneous disease and one of the major causes of cancer-related mortality worldwide. Diffuse-type gastric adenocarcinoma (or poorly cohesive- with independent cells) is characterized by aggressive behavior (rapid invasion, chemoresistance and peritoneal metastasis), as compared with intestinal-subtype adenocarcinoma. Diffuse subtype GC additionally has a substantially increasing incidence rate in Europe and the USA, and was often associated with younger age.
View Article and Find Full Text PDFHeparanase (HPSE), a heparan sulfate-specific endo-β-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans. Suramin, a polysulfonated naphthylurea, is an inhibitor of HPSE with suramin analogues. Our objective was to analyze the HPSE involvement in gastric signet ring cell adenocarcinoma (SRCA) invasion.
View Article and Find Full Text PDFIntroduction: Gastric signet ring cell carcinoma (GSRC) is a distinct entity among of other gastric cancer. With unknown etiopathology, their incidence is increasing and it presents a low sensitivity to chemotherapy.
Aim: Here, we studied the expression of the heparanase (HPA) in cancer tissues from GSRC patients and several cancer cell lines.