Emerging Perspectives of Blockchains in Food Supply Chain Traceability Based on Patent Analysis.

In the field of blockchain (BC) technology application in the food supply chain (FSC), a patent portfolio is collected, described, and analyzed using Latent Dirichlet Allocation (LDA) modeling, with the aim of obtaining insight into technology trends in this emerging and promising field. A patent portfolio consisting of 82 documents was extracted from patent databases using PatSnap software. The analysis of latent topics using LDA indicates that inventions related to the application of BCs in FSCs are patented in four key areas: (A) BC-supported tracing and tracking in FSCs; (B) devices and methods supporting application of BCs in FSCs; (C) combining BCs and other ICT technologies in FSC; and (D) BC-supported trading in FSCs.

Hypomagnesemia in adults of northern Serbia: prevalence, nutritional risk factors, and associated comorbidities.

Introduction: Magnesium (Mg) deficiency is associated with numerous non-communicable diseases. The aim of the study was to estimate the prevalence of hypomagnesemia in the general adult population of Northern Serbia (NS), and to determine the level of Mg in drinking water.

Methods: This is a cross-sectional study with 5,122 adults from the general population.

Assessment of hepatic steatosis algorithms in non-alcoholic fatty liver disease.

Background: In order to optimize the identification of persons with non-alcoholic fatty liver disease (NAFLD), several algorithms for hepatic steatosis were developed. These available algorithms, as well as an algorithm, derived using biochemical and anthropometric data of our participants, are compared in a cross-sectional pilot study.

Material And Methods: We included 77 participants with abdominal obesity: 43 with NAFLD and 33 without NAFLD.

Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-sectional Study.

Background: Chronic kidney disease (CKD) is one of the most significant global health problems accompanied by numerous complicatons, with constant increase in the number of affected people. This number is much higher in early phases of disease and patients are mostly asymptomatic, so early detection of CKD is crucial. The aim was examination of the prevalence of CKD in the general population of males in Vojvodina, based on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR), and exploring the determinants and awareness of CKD.

Cystatin C, vascular biomarkers and measured glomerular filtration rate in patients with unresponsive hypertensive phenotype: a pilot study.

Background: Biomarkers are commonly used to estimate the presence of subclinical cardiovascular disease (CVD) in patients with essential arterial hypertension (HT). In addition to known association between cystatin C and glomerular filtration rate (GFR), elucidating the association between cystatin C and vascular biomarkers (intima-media thickness of common carotid arteries (CCIMT), carotid plaque and renal artery resistance index (RRI)) in patients with unresponsive hypertensive phenotype could be of significant clinical interest.

Methods: Participants (n = 200, median age 58 (52-64) years, 49% female) under treatment with antihypertensive drugs were stratified into two subgroups based on their blood pressure level as having responsive hypertension (RHT - compliant and responsive to treatment, n = 100), or nonresponsive (URHT - compliant but nonresponsive to treatment, n = 100).

THE LABORATORY ASPECTS OF PROTEINURIA.

Introduction: The existence of proteinuria may be overlooked by applying the test strips. The aim of this study has been to determine the discrepancy between the findings ofproteinuria detected by test strips when compared to the results of its testing with the sulfosali- cylic acid.

Material And Methods: The study sample consisted of 1106 subjects, who were divided into the proteinuria positive (test strips showed the presence of isolated proteinuria), and proteinuria negative group (microscopic examination revealed the presence of ≥10 fresh red blood cells4sL, and/or ≥1 dysmorphic erythrocyte/μL, and/or 10≥ leukocytes4uL, and or ≥1 cylinder, and/or ≥ 1 nonsquamous epithelial cells4μL, and/or ≥100 bacteria/μL).

Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data.

Objective: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy.

Methods: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay.

Self-reported and observed seat belt use--A case study: Bosnia and Herzegovina.

The issue of seat belt use in middle- and low-income countries is strongly evident and has as a result higher rates of fatalities and seriously injured on the roads. The first systematic field research of the seat belt use while driving was carried out in Bosnia and Herzegovina, in 2011-2012. Research methodology consisted of two mutually conditioned parts (observation and self-reported behavior).

Glycated hemoglobin A1c as a modern biochemical marker of glucose regulation.

Unlabelled: GLYCATED HEMOGLOBIN STRUCTURE AND SYNTHESIS OF MOLECULE: Glycated hemoglobin A1c, the major fraction of glycated hemoglobin, is formed by irreversible nonenzymatic glycation. Its concentration depends only on the life span of red blood cells and blood glucose levels. CLINICAL SIGNIFICANCE OF GLYCATED HEMOGLOBIN A1c: It is the key parameter for monitoring the regulation of diabetes and for assessing the risk of microvascular complications.

Effect of serum lipid level change on 10-year coronary heart risk distribution estimated by means of seven different coronary risk scores during one-year treatment.

Introduction: This study was done in order to evaluate the effect of serum levels of total cholesterol, triglycerides, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol on 10-year coronary heart disease risk distribution change.

Material And Methods: This study included 110 subjects of both genders (71 female and 39 male), aged 29 to 73, treated at the Outpatient Department of Atherosclerosis Prevention, Centre for Laboratory Medicine, Clinical Centre Vojvodina. The 10-year coronary heart disease risk was estimated on first examination and after one-year treatment by means of Framingham, PROCAM and SCORE coronary risk scores and their modifications (Framingham Adult Treatment Panel III, Framingham Weibul, PROCAM NS and PROCAM Cox Hazards).

[Therapeutic options for treatment of cardiometabolic risk].

Introduction: Numerous epidemiological and clinical studies have shown that increased amounts of fat mass, especially intra-abdominal adipose tissue are associated with various metabolic abnormalities. Dysregulation of adipocytokines secreted by adipose tissue may play an important role in the development of the obesity-associated metabolic syndrome, resulting in insulin resistance, type 2 diabetes, hypertension, hyperlipidemia, and vascular disease. The cardiometabolic risk describes the clustering of risk factors including dyslipidemia, insulin resistance, hypertension, prothrombotic and proinflammatory state, associated with an increased risk for development of cardiovascular disease and type 2 diabetes.

[Biochemical markers of atherosclerotic disease].

Introduction: Although the expanding body of research has established firm evidence for the value of some biochemical markers in patients with cardiovascular disease, it has also deluged the clinical and research communities with candidate biomarkers, but very few of them are likely to survive the test of time as useful clinical tool.

Biochemical Markers In Acute Coronary Syndromes: Acute coronary syndrome refers to a constellation of clinical symptoms caused by acute myocardial ischemia. Guidelines for utilization of biochemical markers in acute coronary syndromes are involved in recommendations for use of biomarkers in the initial evaluation of patients with nontraumatic chest symptoms, for diagnosis of myocardial infarction, as well as recommendations for early risk stratification of subsequent death and/or recurrent ischemic event.

[Influence of fibrinolitic potential reduction in ischemic brain disease development].

Introduction: Vascular brain disease are the third leading cause of morbidity and mortality today. Among them ischemic brain disease caused mostly by cerebral atherosclerosis makes almost 80%. The main risk factors for this disease are arterial hypertension, dislipoproteinemia and diabetes but, recently hemostatic system disorders have also been underlined, especially fibrinolytic disorders.

[The role of holotranscobalamin in examination of vitamin B12 status].

Introduction: Holotranscobalamin contains biologically available cobalamin because only holotranscobalamin promotes the uptake of the cobalamin therein by all cells, via specific receptors. Therefore holotranscobalamin has been proposed as a potentially useful alternative indicator of vitamin B12 status. The aim of the present study was to assess usefulness of holotranscobalamin in the evaluation of vitamin B12 status.

[Correlation between C-reactive protein levels with leading risk factors for cardiovascular disease in men].

Introduction: The aim of this study was to estimate the correlation between C-reactive protein levels and leading risk factors for cardiovascular disease in men.

Material And Methods: The study included 183 working capable men chosen randomly from the regular systematical check-up in Health Centre Banja Luka in 2006. Standard laboratory methods were used to establish the following: total cholesterol, triglyceride and HDL-cholestreol level and LDL-cholesterol level was calculated.

[Laboratory medicine today].

Introduction: Laboratory medicine today is a well-established branch of medicine which has an important role in improving of diagnostics, research and all forms and levels of education at the Faculty of Medicine in Novi Sad. The value of laboratory medicine is particularly important in team work within the Clinical Center of Novi Sad, nowadays - Clinical Center of Vojvodina.

Institute Of Laboratory Medicine Of The Clinical Center Of Vojvodina: The institute of Laboratory Medicine of the Clinical Center of Vojvodina is a contemporary organized, integrated system of laboratories, employing highly educated professional staff and with the exception of the nuclear-medicine laboratory, has all necessary equipement for providing the highest level of laboratory diagnostics.

[Lipoprotein(a): a link between thrombogenesis and atherogenesis].

Introduction: It is well known that numerous mechanisms of thrombogenesis can participate in every stage of atherosclerotic disease. The discovery of Lp(a) lipoprotein and its structural similarity with plasminogen suggests another pathogenic link between atherogenesis and thrombogenesis.

Some Characteristics Of Lp(a) Lipoprotein: This lipoprotein is present in the whole human population in a wide range of plasma concentrations.

[The correlation between lifestyle and lipid profile].

Introduction: The aim of this study was to estimate if negative lifestyle habits such as alcohol consumption, smoking and physical inactivity affect the lipid profile values.

Material And Methods: The study included 250 workers on regular examination in the Gradiska Health Center in the period from 2001 to 2002. There were 113 (45.

[Clinical trials of statins and fibrates --a meta-analysis].

Introduction: Several clinical trials of hypolipidemics showed a decrease in mortality by 30-40%, while others showed detrimental or no effects. The question remains: which trial should be the basis of clinical decision making in the choice of hypolipidemic therapy?

Material And Methods: Meta-analysis is a method for combining research results of several studies. Effects of statins and fibrates with respect to placebo, were assessed by systematic literature review and meta-analysis.

[Endothelial dysfunction and diabetes].

ENDOTHELIAL FUNCTION AND DYSFUNCTION: During the past two decades, there has been an increasing recognition of the importance of normal endothelial function in the maintenance of vascular homeostasis and vascular health. Abnormalities in the function of endothelium have been recognized in a number of conditions. One of the most important abnormalities of endothelial dysfunction appears to be changes in the bioavailability of nitric oxide.

[Analysis of lipid status parameters in relation to gender and age in the working population of district of Gradiska].

Introduction: The aim of this investigation was to establish the frequency of hyperlipoproteinemias, as well as the distribution of desired, elevated and high risk values of certain lipid status parameters among working population of the Gradiska municipality with age and sex distribution.

Material And Methods: This investigation included 250 workers, 109 male and 141 female, 25-60 years of age of the Gradiska municipality on a regular checkup. Standard biochemical methods were used to determine values of total serum cholesterol, triglycerides and HDL cholesterol.

[Specificity of lipid and lipoprotein status in healthy students at the University of Novi Sad].

Introduction: The aim of this study was to determine the frequency of hyperlipoproteinemias and normolipidemic dyslipoproteinemias, and distribution of desirable, borderline and high-risk values of certain lipid status parameters in healthy young individuals.

Material And Methods: In this investigation we examined 213 students of the University of Novi Sad of both genders, 20-30 years of age. Standard biochemical methods were used to determine values of total serum cholesterol, triglycerides, HDL cholesterol, and lipoproteins by cellulose acetate electrophoresis.

[Hyperinsulinemia as a key factor in the development of many metabolic disorders].

Insulin resistance and consequent hyperinsulinemia present a frequent disorder and according to some investigations it is present in a quarter of whole population. Leaving aside numerous genetic syndromes caused by pronounced insulin resistance, this paper surveys the influence of specific arrangement of fat tissue in the development of this disorder, its role in insulin-independent form of diabetes, development of lipidic and lipoproteinic disorders, in the essential arterial hypertension, and finally, in the appearance of accelerated and premature atherosclerosis. Further intensive investigations of this problem will probably result in achieving a definite explanation of the importance of hyperinsulinemia as a marker of cardiovascular risk.

[The metabolic syndrome and hyper-Lp(a)-lipoproteinemia in peripheral obliterative atherosclerosis: 2 case reports].

One of the characteristics of peripheral vascular disease in diabetic patients is that it occurs at the time of detection of diabetes mellitus. As one of the possible pathogenic mechanisms, in non-smokers, is the sol-called metabolic syndrome (obesity, disorders in regard to metabolism of lipids and carbohydrates and hypertension). Lipoprotein Lp(a) is the most atherogenic among lipoproteins.