[Peculiarities of sexual development in Caucasoids and Ural Mongoloids in Northern Russia].

A review of the domestic scientific literature concerning forensic medical aspects of the girls' pubertal development is presented. The interplay of various social factors is shown to influence the rate of sexual maturation and the age at which puberty begins. Racial differences of these parameters are demonstrated.

[Forensic medical examination in cases of sexual abuse].

The article presents the analysis of forensic medical expert practice in the field of sexual abuse. Drawbacks in expert examinations, official decisions on such examinations, low expertise of forensic medical personnel in sexual crime, lack of tools for genital and anal examination are analysed and methods of correction of this situation are proposed.

[ACE gene I/D-polymorphism and hereditary predisposition to myocardial infarction].

The authors compare distribution of genotype frequencies and alleles of I/D of ACE gene polymorphism in patients with various forms of ischemic heart disease (IHD): with acute myocardial infarction (MI), stable effort angina (functional class II-III); in patients with postinfarction cardiosclerosis (PICS). A relationship was found between I/D polymorphism and acute MI. Frequency of DD genotype in MI patients was 0.

[HindIII DNA-polymorphism of lipoprotein lipase gene in elderly patients with ischemic heart disease].

Aim: To determine incidence of HindIII alleles of lipoprotein lipase (LPL) in Russian elderly patients with stable effort angina (SEA) functional class II-III regarding lipid metabolism.

Material And Methods: Genotyping by LPL gene was performed in 103 patients with SEA. Of them 13 patients survived myocardial infarction (MI), 29 patients had diabetes mellitus.

[Regional forensic medical characteristics of sexual maturity].

Published data on sexual maturity of women in the North are reviewed. The authors analyze the findings of their studies and the anthropometric parameters of sexual maturity recorded in Regulations of Forensic Medical Obstetrical and Gynecological Expert Evaluations (1966) and find essential differences in the values of some parameters as regards the population of the Russian European North. The authors propose revision of the current Regulations in order to define regional standards.

[Medicosocial aspects of sexual abuse crimes in Arkhangel'sk].

The criminological and victim sides of sexual abuse crimes in Archangelsk are analyzed and the data are compared with the data for Russia and for St. Petersburg. Seasonal patterns of rapes and violations and the most vulnerable age of victims have been determined.

Evidence for selection in evolution of alpha satellite DNA: the central role of CENP-B/pJ alpha binding region.

Conservation of DNA segments performing sequence-related functions is a landmark of selection and functional significance. Phylogenetic variability of alpha satellite and apparent absence of conserved regions calls its functional significance into question, even though sequence-specific alpha satellite-binding proteins pJ alpha and CENP-B have been discovered. Moreover, the function of pJ alpha is obscure and CENP-B binding satellite DNA, which is thought to participate in centromere formation, is found only in few species and not necessarily in all chromosomes.

[Method of diagnosing aneuploidies using in situ hybridization: analysis of interphase nuclei].

The possibility of determining chromosomal sex using in situ hybridization of X-specific alphoid DNA probe with interphase human nuclei is studied. Total number of nuclei under study being 14806, more than 85 percent of female ones and more than 95 per cent of male ones are shown to contain two and one grain clusters, respectively. The minor nuclear classes, i.

[Human alpha-satellite DNA specific to chromosomes 13 and 21: use for the analysis of polymorphism of acrocentric chromosomes and the origin of the additional chromosome 21 in Down's syndrome].

Chromosomal distribution of cloned human alpha-satellite DNA alpha R1-6 has been studied by in situ hybridization technique. The sequence under study has been shown to be predominantly located in the centromeric regions of chromosomes 13 and 21. Intercellular variability of labelling patterns in every person under analysis being insignificant, there exists strong individual variability of interchromosomal distribution of the satellite.

[Intraspecies variability of the normal human karyotype].

On the basis of data from literature the number of different normal structural variants of each human chromosome is calculated. Assuming independent combination of chromosome variants, the number of possible combinations of variants of all 22 pairs of autosomes and the probability of an individual to be hormozygous for the most frequent variants of all the autosome pairs simultaneously are estimated. The results obtained show that nearly each individual possesses a unique karyotype--a unique set of properties of chromosome heterochromatic regions.

[Spiralization dynamics of the eu- and heterochromatin of heteromorphic homologs of the 1st pair of human chromosomes].

Peculiarities of mitotic spiralization of eu- and heterochromatic parts of heteromorphic homologous chromosomes No 1 are investigated. The homologues differ in size of their centromeric heterochromatin segments. In the spiralization range studied (the total lengths of chromosome pair equal to 8.

[Studies in the automation of human chromosomal analysis. II. The development and testing of a system for the semiautomatic measurement of chromosomes].

The elaboration and testing the "PAUK" system intended for human chromosome measurement is described. The system is based on the semi-automatic measurement projector and computer "Minsk-22". Chromosomes of 83 cells were measured.

[The relationship between the frequency of participation of acrocentric chromosomes in formation of satellite associations and the duration of human lymphocyte cultivation with phytohemmaglutinin].

All acrocentrics were shown to take part in the formation of satellite association at the 52nd, 72nd and 90th hr of human lymphocytes culturing, in the first mitosis with equal frequency but having different associative capacity in further mitoses. It seems likely that a single nucleolus in the lymphocytes at initial stage of activation, the high frequency of satellite associations, and a random participation of acrocentrics in the associations in first mitosis are due to that all acrocentrics form association in small lymphocytes which are sensitive to PHA.