Publications by authors named "Deri Islami"
Article Synopsis
- Monoamine oxidase (MAO) is important for breaking down neurotransmitters and is a potential target for treating neurodegenerative diseases like depression and Alzheimer's.
- The study examined chromone-based compounds to see how effectively they inhibit MAO-A and MAO-B, identifying several promising derivatives through molecular docking techniques.
- A quantitative structure-activity relationship (QSAR) model was developed to predict the effectiveness of these compounds, showing strong validation with experimental data and highlighting key molecular features that enhance their inhibitory effects.
Pinocembrin (PCB), a flavonoid known for its anti-inflammatory properties, has been approved for various clinical trial applications. To evaluate deeper into the anti-inflammatory potential of the specific enantiomer of natural PCB, we conducted the first investigation into the efficacy of the pure enantiomer (2)-PCB in modulating inflammatory mediators induced by lipopolysaccharide (LPS) in both murine RAW 264.7 and human U937 macrophage cell lines.
View Article and Find Full Text PDFChromones are promising for anticancer drug development. 12 chromone-based compounds were synthesized and tested against cancer cell lines. Compound showed the highest cytotoxicity (LC 3.
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