Publications by authors named "Dergham M"

Article Synopsis
  • Supramolecular interactions, driven by non-covalent forces like hydrophobic effects and hydrogen-bonding, play a crucial role in various intracellular biological pathways.
  • In-cell supramolecular self-assembly utilizes host-guest interactions and other factors to create synthetic, biocompatible macromolecules that can manipulate cell behavior and biological functions.
  • The review highlights the latest advancements in this field, particularly how supramolecular self-assembly can be activated by different stimuli, including changes in pH, reactive oxygen species, enzymes, and light.
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Anomalies of the aortoiliac arteries are rarely reported and are generally discovered incidentally on imaging performed mostly for investigation of other medical concerns. While aortic bifurcation is typically reported at the fourth lumbar vertebra, variations are possible. We present a case with very low aortic bifurcation, almost at the level of S2, with various other anomalies including a corkscrew left common iliac artery passing just anterior to the bladder dome with pulsation noted during cystoscopy.

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Giant multilocular cystadenomas of the prostate or seminal vesicles are rarely reported in literature. We present a case of a 76-year-old male presenting with lower urinary tract symptoms initially perceived as symptoms of benign prostatic hyperplasia. The patient was investigated by employing a multimodality imaging approach of the prostate that included ultrasound, computed tomography, and magnetic resonance imaging, which resulted in an incidental finding of large multiloculated benign cysts originating from the prostate, confirmed by pathological study.

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Epithelioid osteoblastoma is a clinically aggressive subtype of osteoblastoma that favors the mandible and the maxilla. Its histologic features lie on a spectrum between conventional osteoblastoma and low-grade osteosarcoma, thus making it difficult at times to confirm the diagnosis. It is known to have a high risk of recurrence after surgical resection, but it is a benign entity and does not have the propensity to metastasize.

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Pancreaticoduodenal artery aneurysms (PDA) are rare visceral aneurysms. Celiac trunk stenosis represents a common attributable aetiology for those aneurysms. Therefore, an alternative treatment approach, which differs from those isolated aneurysms, is recommended.

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Article Synopsis
  • The study investigated the harmful effects of different air pollution particulate matter (PM2.5-0.3) samples during spring/summer and autumn/winter across rural, urban, and industrial settings.
  • The physicochemical properties of PM were linked to their sources and seasonal variations, revealing that industrial activities and heavy traffic were significant contributors to health risks.
  • Findings indicated that oxidative damage and cytokine secretion in human bronchial cells were heightened by PM2.5-0.3 exposure, but the relationship between their chemical composition and health outcomes was complex and suggested PM mass alone is insufficient to gauge health impacts.
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Airborne particulate matter has recently been classified by the IARC as carcinogenic to humans (group 1). However, the link between PM chemical composition and its carcinogenicity is still unclear. The aim of the present study was to evaluate and to compare genotoxic potencies of 6 native PM samples collected in spring-summer or autumn-winter, either in industrial, urban or rural area.

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Airborne particulate matter (PM) toxicity is of growing interest as diesel exhaust particles have been classified as carcinogenic to humans. However, PM is a mixture of chemicals, and respective contribution of organic and inorganic fractions to PM toxicity remains unclear. Thus, we analysed the link between chemical composition of PM samples and bulky DNA adduct formation supported by CYP1A1 and 1B1 genes induction and catalytic activities.

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Compelling evidence indicates that exposure to air pollution particulate matter (PM) affects human health. However, how PM composition interacts with PM-size to cause adverse health effects needs elucidation. In this study, we were also interested in the physicochemical characteristics and toxicological end points of PM₂.

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