[Peptidergic modulation of the hippocampus synaptic activity].

Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells.

[Long-term pathomorphologic changes in the neurons of the rat brain following irradiation with carbon ions and gamma rays].

Quantitative and qualitative morphological changes in neurons and glia of rat brain were studied one month after exposure to accelerated carbon ions 4 GeV/nucleon (LET-76 MeV cm2.r-1) and gamma-radiation (137Cs, 0.25 to 4.

[Incidence of morphologic changes in cerebral cortex neurons of the rat exposed to accelerated carbon ions].

Structural lesions in neurons of the brain cortex of rats were investigated 1 and 3 months after their exposure to accelerated carbon ions with the energy 320 MeV/nuclon 10(4) particles/cm2 (LET = 120 MeVcm2/g) as well as to gamma-radiation in the dose 1.0 Gy. The irradiated animals showed morphofunctional, dystrophic and reparative lesions in neurons.

[Various characteristics of morphological changes in the brain in newborn infants with intrauterine and perinatal damage of the central nervous system].

Pathomorphological examination of the brain was carried out in 8 infants with severe forms of perinatal encephalopathy who died on the 17-th-25th day of life from intercurrent diseases. The investigation revealed a combination of circulatory disorders, dystrophic changes in neurons, fibers, and glia as well as focal productive inflammation of the medulla (predominantly in the area of lateral ventricle walls). An original technique was developed for the determination of the volumetric density of Betz's cells.

[Modular organization of callosal neurons in the sensomotor area of the cerebral cortex in the rabbit].

The density of distribution of callosal neurons in rabbit sensorimotor cortex was studied by means of horseradish peroxidase injection into the homotopic cortical area. The irregularity of density was evaluated visually and/or computed. Labelled callosal units were mostly small and medium-size pyramidal cells located primarily in layer III-IV and more rarely in layers V and VI.

[Comparative analysis of the statistical parameters of synaptic transmission of central neurons in the snail Helix lucorum and in the rabbit].

Comparative analysis of the parameters of synaptic transmission in the central synapses of the snail (parietal ganglia) and in the brain of rabbit (hippocamp and sensorymotor cortex) has been made. Both differences and common features were revealed in synaptic organization of these two objects. Functional re-arrangements may alleviate differences between central synapses of the snail and rabbit.

[Comparative characteristics of 2 morphometric methods of assessing the degree of liver fatty distrophy].

The fat content in the liver of white male Wistar rats was measured over time (1, 2, 4, 8 and 14 days) after a single exposure to CCl4 within a wide concentration range (from 30 to 25700 mg/m3) by the two morphometric techniques: subjective-graduation and semi-automatic evaluation of the volumetric fat fraction, using a TAS unit (Leitz-Wetzlar). The results obtained with both the methods indicate that the CCl4 concentration equal to 260 mg/m3 is the threshold one as shown by the morphological signs of liver fatty dystrophy. The semi-automatic method offered enables an objective evaluation of the findings, making the research time shorter.

[Parameters of a model of transmitter depletion in synapses of identified snail neurons].

Unitary EPSP were recorded in two identified neurons of the snail ganglia after stimulation of an identified presynaptic neuron. Low-frequency EPSP depression was found in the course of repetitive stimulation (0.1-0.

[Structure of the theoretical distributions of postsynaptic potential amplitudes upon quantum analysis].

It is suggested that formulas commonly used to calculate theoretical amplitude distributions of postsynaptic potentials (PSPs) for their further quantum analysis lead to the overestimation of the quantum value variations (sigma nu) and neglect the variations of a noise level (sigma 2n). A proper formula taking into account both parameters in proposed. The necessity to consider sigma 2n is shown by statistical analysis of "individual" and "minimal" PSPs recorded in the neurons of the central ganglion of the snail and hippocampal neurons of the rabbit.

[Quantitative characteristics of ultrastructural changes in axo-dendritic synapses under the influence of tetanus toxin].

Changes in synaptic ultrastructure of the external geniculate body (EGB) were investigated in rats when a generator of pathologically intensified excitation (GPIE) was produced in this nucleus under the influence of tetanus toxin (TT). At the period of pronounced convulsive activity (24 h after TT injection), synaptic changes were estimated electronmicroscopically and with quantitative comparison of the materials from three groups. The first group included EGB synapses where TT was injected, the second group included contralateral EGB synapses and the third included EGB from the rats injected with inactivated toxin.