Inhalation delivery of nucleic acid gene therapies in preclinical drug development.

Introduction: Inhaled gene therapy programs targeting diseases of the lung have seen increasing interest in recent years, though as of yet no product has successfully entered the market. Preclinical research to support such programs is critically important in maximizing the chances of developing successful candidates.

Areas Covered: Aspects of inhalation delivery of gene therapies are reviewed, with a focus on preclinical research in animal models.