The genome sequence of a cased caddisfly, Curtis, 1834.

We present a genome assembly from an individual male (cased caddisfly; Arthropoda; Insecta; Trichoptera; Molannidae). The genome sequence is 994.9 megabases in span.

The genome sequence of a cased caddisfly, (Linnaeus, 1758).

We present a genome assembly from an individual male (cased caddisfly; Arthropoda; Insecta; Trichoptera; Leptoceridae). The genome sequence is 665.1 megabases in span.

Effect of population breast screening on breast cancer mortality up to 2005 in England and Wales: an individual-level cohort study.

Background: Population breast screening has been implemented in the UK for over 25 years, but the size of benefit attributable to such programmes remains controversial. We have conducted the first individual-based cohort evaluation of population breast screening in the UK, to estimate the impact of the NHS breast screening programme (NHSBSP) on breast cancer mortality.

Methods: We followed 988 090 women aged 49-64 years in 1991 resident in England and Wales, who because of the staggered implementation of the NHSBSP, included both invited subjects and an uninvited control group.

Review of the national external quality assessment (EQA) scheme for breast pathology in the UK.

Background: The National Health Service Breast Screening Programme (NHSBSP; pathology) external quality assurance (EQA) scheme aims to provide a mechanism for examination and monitoring of concordance of pathology reporting within the UK. This study aims to review the breast EQA scheme performance data collected over a 24-year period following its introduction.

Methods: Data on circulations, number of cases and diagnosis were collected.

Evaluation of the use of digital images for a national prostate core external quality assurance scheme.

Aims: To evaluate the use of virtual images as an alternative to glass slides to expand the number of participants in the External Quality Assurance Scheme for prostatic biopsies.

Methods And Results: Benign and neoplastic cases, previously circulated as glass slides, were selected to include cases that had demonstrated a high level of agreement (n = 10) and a lesser degree of agreement (n = 10). Whole slide virtual images were circulated to 68 pathologists; 51 responses were returned.

Measuring interobserver variation in a pathology EQA scheme using weighted κ for multiple readers.

Background: A Urological Pathology External Quality Assurance (EQA) Scheme in the UK has reported observer variation in the diagnosis and grading of adenocarcinoma in prostatic biopsies using basic κ statistics, which rate all disagreements equally.

Aim: The aim of this study is to use customised weighting schemes to report κ statistics that reflect the closeness of interobserver agreement in the prostate EQA scheme.

Methods: A total of 83, 114 and 116 pathologists took part, respectively, in three web-based circulations and were classified as either expert or other readers.

Effects of a prostate awareness pilot on GP consultations and PSA requests.

Background: A Department of Health prostate awareness initiative, piloted in Coventry in 2006, promoted reporting of symptoms of benign prostatic hyperplasia, prostatitis and prostate cancer to GPs without causing sudden increases in workload. Qualitative evaluation showed a wide distribution of materials.

Objectives: Evaluation of effects of the pilot on rates of GP urological consultations, prescriptions and prostate-specific antigen (PSA) requests in general practice in Coventry and three control areas.