Ferric ions crosslinked hyaluronic acid beads: potentials for drug delivery use.

Introduction And Purpose: Despite the attractive properties of hyaluronic acid (HA), The preparation of HA beads is still challenging. This article reports the preparation of pH-sensitive gel HA beads. The ionic gelation method was used to prepare the HA gel beads using ferric ions.

The Influence of Polymers, Surfactants, and Other Excipients on Naproxen Sodium Release from Matrices Prepared and the Effect of These Additives on the Swelling Rate of the Tablet.

This study aimed to develop controlled-release matrix tablets of naproxen using the hydrophilic polymer sodium carboxymethylcellulose, investigate the impact of surfactants and other excipients on drug release and swelling rate, and determine the drug release mechanism. Naproxen matrices were formulated by the direct compression technique with different ratios of polymer sodium carboxymethylcellulose and other excipients. Drug release, swelling behavior, and release mechanism were assessed using an acidic dissolution medium.

Modafinil-excipient compatibility study using differential scanning calorimetry.

Drug excipient compatibility studies are considered important in successful formulation of drug products. Suggested methods for this purpose are thermal techniques under isothermal or nonisothermal conditions. In this study, modafinil, a wakefulness-promoting drug, was investigated under nonisothermal conditions using differential scanning calorimetry.

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification.

Sex hormone disruptors (xenoestrogens) are a global concern due to their potential toxicity. However, to date, there has been no study to investigate the presence of xenoestrogen pollutants in the Jordanian water system. Samples in triplicates were collected from six locations in Jordan, including dams, surface water, tap or faucet water, and filtered water (drinking water-local company).

Lactic acid-induced modifications in films of Eudragit RL and RS aqueous dispersions.

Eudragit RL (ERL) and RS (ERS) are polymethacrylate co-polymers, used in film coating of sustained release dosage forms, possessing some hydrophilic properties due to the presence of quaternary ammonium groups (QAG), where ERL contains more of such groups, hence more permeable, than ERS. However, because these groups ionize in solution, they undergo electrostatic interaction with negatively charged species. This phenomenon was utilized in this study to introduce modification in the film properties of ERL and ERS by interaction with lactic acid (LA).