Publications by authors named "Dequan Shen"
Article Synopsis
- The study investigates how lifestyle choices and air pollution impact adult asthma progression, focusing on new cases of asthma and hospital admissions.
- Using data from 176,800 participants, the research highlighted that unhealthy lifestyles and air pollution, particularly from traffic-related particulate matter (PM), significantly increase asthma risk.
- The findings emphasize the need for strategies to reduce air pollution, promote healthy living, and address socioeconomic disparities to help prevent and manage asthma effectively.
Our previous study demonstrated that adenovirus-delivered GFP nuclear heme oxygenase-1 (nuclear HO-1, NHO-1) fragments lacking 23 amino acids at the C-terminus (Ad-GFP-HO-1C[INCREMENT]23) showed the potential therapeutic effects mediated by its improvement of the blood-spinal cord barrier (BSCB) integrity. However, the NHO-1-mediated molecular mechanism in regulating the BSCB function remains unclear. The BSCB model in vitro was established via a coculture of primary rat brain microvascular endothelial cells (RBMECs) and spinal cord astrocytes on transwell system.
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