Publications by authors named "Dequan Lou"
Article Synopsis
- Single-cell RNA sequencing (scRNA-seq) is a powerful technique that helps identify rare cells, discover new cellular subclusters, and study gene expression in individual cells, revealing shifts in cellular phenotypes and subtype heterogeneities.* -
- Since its introduction in 2009, scRNA-seq has evolved with advancements like cell-specific barcodes and droplet-based systems, despite challenges such as cellular stress during sample preparation.* -
- Recent innovations in spatial transcriptomics enhance understanding of cellular organization by preserving the spatial context of gene activity, leading to promising future research directions that combine this data with other omics for deeper insights.*
Monocyte Production of C1q Potentiates CD8 T-Cell Function Following Respiratory Viral Infection.
Am J Respir Cell Mol Biol
September 2024
Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus, we identified recruitment of a C1q-expressing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8 T-cell function.
View Article and Find Full Text PDFUnlabelled: Human metapneumovirus (HMPV) is a primary cause of acute respiratory infection, yet there are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV are poorly characterized, and further understanding could identify important antiviral pathways. Type III interferon (IFN-λ) displays potent antiviral activity against respiratory viruses and is being investigated for therapeutic use.
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- Klebsiella pneumoniae is a Gram-negative bacterium that can cause serious infections, and STAT1 is a key transcription factor that helps regulate T cell activity during infection.
- Researchers used a mouse model to show that a lack of STAT1 leads to increased neutrophil activity and early recruitment to the lungs, which precedes serious bacterial infection and lung damage.
- They also discovered that while IL-17 from other immune cells is crucial for combating the infection, dysfunctional CD4+ T cell responses due to STAT1 deficiency may worsen the situation, highlighting the complex role of STAT1 in managing immune responses during bacterial infections.
Klebsiella pneumoniae (KP) presents a global health threat, leading to significant morbidity and mortality due to its multidrug-resistant profile and the limited availability of therapeutic options. To eliminate KP lung infection, the host initiates a robust inflammatory response. One of the host's mechanisms for mitigating excessive inflammation involves the RNA-binding protein regnase-1 (Reg1, MCPIP1, or ZC3H12A).
View Article and Find Full Text PDFRespiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus (HMPV), we identified recruitment of a C1q-producing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8 T cell function.
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