The NEOTAX phase 2 study explored how effective and safe the combination of toripalimab and axitinib is for patients with clear cell renal cell carcinoma and inferior vena cava tumor thrombus.
Out of 25 patients, 44% showed a reduction in thrombus level, with a median decrease in tumor thrombus length of 2.3 cm, while 61.9% had changes in their surgical approach.
The study found promising progression-free survival rates (25.3 months median; 89.1% at 1 year) and noted no severe treatment-related adverse events, suggesting that the combination therapy effectively downstages the tumor and improves surgical outcomes.