The Value of Aortic Volume and Intraluminal Thrombus Quantification for Predicting Aortic Events after Endovascular Thoracic Aneurysm Repair.

To assess the ability of the aortic aneurysm volume (AAV), aneurysmal lumen volume (ALV), and aneurysmal thrombus volume (ATV) to predict the need for aortic reintervention when using the maximal aortic diameter as a reference. This monocentric retrospective study included 31 consecutive patients who underwent successful thoracic endovascular aortic repair (TEVAR) to treat an atheromatous thoracic aortic aneurysm. All patients underwent clinical and computed tomography angiography (CTA) for 3 years after TEVAR.

Volume Analysis to Predict the Long-Term Evolution of Residual Aortic Dissection after Type A Repair.

Background: The aim of this study was to evaluate the aortic diameter and volume during the first year after a type A repair to predict the long-term prognosis of a residual aortic dissection (RAD). Methods: All patients treated in our center for an acute type A dissection with a RAD and follow-up > 3 years were included. We defined two groups: group 1 with dissection-related events (defined as an aneurysmal evolution, distal reintervention, or aortic-related death) and group 2 without dissection-related events.

Numerical modeling of residual type B aortic dissection: longitudinal analysis of favorable and unfavorable evolution.

Residual type B aortic dissection was numerically investigated to highlight the contribution of biomechanical parameters to the pathology's evolution. Patient-specific geometries from cases involving both favorable and unfavorable evolution were modeled to assess their hemodynamic features. This original approach was supported by a longitudinal study confirming the association between morphological changes, hemodynamic features, adverse clinical outcomes, and CT-angioscan observations on the same patient.

Results of a prospective follow-up study after type A aortic dissection repair: a high rate of distal aneurysmal evolution and reinterventions.

Objectives: We investigated the anatomical evolution of residual aortic dissection after type A repair and factors associated with poor prognosis at a high-volume aortic centre.

Methods: Between 2017 and 2019, all type A aortic dissections were included for prospective follow-up. Patients without follow-up computed tomography (CT) scan available for radiological analysis and patients without residual aortic dissection were excluded from this study.

A 10-Year Aortic Center Experience with Hybrid Repair of Chronic "Residual" Aortic Dissection After Type A Repair.

Purpose: Hybrid aortic arch repair in patients with chronic residual aortic dissection (RAD) is a less invasive alternative to conventional surgical treatment. The aim of this study was to describe the short-term and long-term results of hybrid treatment for RAD after type A repair.

Methods: In this retrospective single-center cohort study, all patients treated for chronic RAD with hybrid aortic arch repair were included.

Side-dependent effect in the response of valve endothelial cells to bidirectional shear stress.

Endothelial cells covering the aortic and ventricular sides of the aortic valve leaflets are exposed to different stresses, in particular wall shear stress (WSS). Biomechanical stimuli actively regulate valve tissue structure and induce remodeling events leading to valve dysfunction. Endothelial to mesenchymal transformation (EndMT), for example, has been associated with aortic valve disease.

Mechanical characterisation of human ascending aorta dissection.

Mechanical characteristics of both the healthy ascending aorta and acute type A aortic dissection were investigated using in vitro biaxial tensile tests, in vivo measurements via transoesophageal echocardiography and histological characterisations. This combination of analysis at tissular, structural and microstructural levels highlighted the following: (i) a linear mechanical response for the dissected intimomedial flap and, conversely, nonlinear behaviour for both healthy and dissected ascending aorta; all showed anisotropy; (ii) a stiffer mechanical response in the longitudinal than in the circumferential direction for the healthy ascending aorta, consistent with the histological quantification of collagen and elastin fibre density; (iii) a link between dissection and ascending aorta stiffening, as revealed by biaxial tensile tests. This result was corroborated by in vivo measurements with stiffness index, β, and Peterson modulus, E, higher for patients with dissection than for control patients.

Assessment of intervertebral disc degeneration-related properties using finite element models based on [Formula: see text]-weighted MRI data.

Quantitative magnetic resonance imaging (MRI) provides useful information about intervertebral disc (IVD) biomechanical properties, especially those in relation to the fluid phase. These properties may improve IVD finite element (FE) models using data closer to physiological reality. The aim of this study is to investigate IVD degeneration-related properties using a coupling between MRI and FE modeling.

Biaxial tensile tests of the porcine ascending aorta.

One of the aims of this work is to develop an original custom built biaxial set-up to assess mechanical behavior of soft tissues. Stretch controlled biaxial tensile tests are performed and stereoscopic digital image correlation (SDIC) is implemented to measure the 3D components of the generated displacements. Using this experimental device, the main goal is to investigate the mechanical behavior of porcine ascending aorta in the more general context of human ascending aorta pathologies.

CCM proteins control endothelial β1 integrin dependent response to shear stress.

Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations. Endothelial cells adapt to shear stress by remodeling their cytoskeletal components and subsequently by changing their shape and orientation. We demonstrate that β1 integrin activation is critically controlled during the mechanoresponse of endothelial cells to shear stress.

Examination of factors in type I endoleak development after thoracic endovascular repair.

Objective: The objective of this study was to assess the effects of operative indication, anatomy, and stent graft on type I endoleak occurrence after thoracic endovascular aortic repair.

Methods: A retrospective review was conducted of patients admitted for thoracic endovascular aortic repair between 2007 and 2013. All computed tomography angiography imaging was analyzed for the presence of endoleak and measurement of diameters and lengths.

Flow of a blood analogue fluid in a compliant abdominal aortic aneurysm model: experimental modelling.

The aim of this work is to develop a unique in vitro set-up in order to analyse the influence of the shear thinning fluid-properties on the flow dynamics within the bulge of an abdominal aortic aneurysm (AAA). From an experimental point of view, the goals are to elaborate an analogue shear thinning fluid mimicking the macroscopic blood behaviour, to characterise its rheology at low shear rates and to propose an experimental device able to manage such an analogue fluid without altering its feature while reproducing physiological flow rate and pressure, through compliant AAA. Once these experimental prerequisites achieved, the results obtained in the present work show that the flow dynamics is highly dependent on the fluid rheology.

New insights into the understanding of flow dynamics in an in vitro model for abdominal aortic aneurysms.

An in vitro dynamics set-up of the flow in a compliant abdominal aortic aneurysm (AAA) model with an anterior posterior asymmetry, aorto-iliac bifurcation, and physiological inlet flow rate and outlet pressure waveforms was developed. The aims were first to show that the structural mechanical behavior of the used material to mimic the AAA wall was similar to this of patients with AAA and then to study the influence of the aorto-iliac bifurcation presence and to study the influence of the imbalanced flow rate in the iliac branches on the AAA flow field. 3D visualizations, never performed in the literature, have clearly put into evidence the development of a vortex ring generated at the AAA proximal neck during the decelerating phase of flow rate, which detaches and progresses downstream during the cardiac cycle, impinges on the anterior wall in the distal AAA region, breaks up, and separates into two vortices of which one rolls on upstream along the anterior wall.

Stereoscopically observed deformations of a compliant abdominal aortic aneurysm model.

A new experimental setup has been implemented to precisely measure the deformations of an entire model abdominal aortic aneurysm (AAA). This setup addresses a gap between the computational and experimental models of AAA that have aimed at improving the limited understanding of aneurysm development and rupture. The experimental validation of the deformations from computational approaches has been limited by a lack of consideration of the large and varied deformations that AAAs undergo in response to physiologic flow and pressure.

Numerical and experimental study of blood flow through a patient-specific arteriovenous fistula used for hemodialysis.

Arteriovenous fistula (AVF) pathologies related to blood flow necessitate valid calculation tools for local velocity and wall shear stress determination to overcome the clinical diagnostic limits. To illustrate this issue, a reconstructed patient-specific AVF was investigated, using computational fluid dynamics (CFDs) and particle image velocimetry (PIV). The aim of this study was to validate the methodology from medical images to numerical simulations of an AVF by comparing numerical and experimental data.

Validation of a numerical 3-D fluid-structure interaction model for a prosthetic valve based on experimental PIV measurements.

A numerical 3-D fluid-structure interaction (FSI) model of a prosthetic aortic valve was developed, based on a commercial computational fluid dynamics (CFD) software program using an Arbitrary Eulerian Lagrangian (ALE) formulation. To make sure of the validity of this numerical model, an equivalent experimental model accounting for both the geometrical features and the hydrodynamic conditions was also developed. The leaflet and the flow behaviours around the bileaflet valve were investigated numerically and experimentally by performing particle image velocimetry (PIV) measurements.

Analysis of blood flow behaviour in custom stent grafts.

Endovascular aneurysm repair (EVAR) is an attractive alternative to open surgery for treating abdominal aortic aneurysms (AAAs). However, the implantation of stent grafts into AAAs can result in post-operative complications such as stent graft migration, rupture or endoleak. EVAR has therefore been carried out only on selected patients.

Nutrient distribution and metabolism in the intervertebral disc in the unloaded state: a parametric study.

A 2-D finite element model for the intervertebral disc in which quadriphasic theory is coupled to the transport of solutes involved in cellular nutrition was developed for investigating the main factors contributing to disc degeneration. Degeneration is generally considered to result from chronic disc cell nutrition insufficiency, which prevents the cells from renewing the extracellular matrix and thus leads to the loss of proteoglycans. Hence, the osmotic power of the disc is decreased, causing osmomechanical impairments.

Influence of wall compliance on hemodynamics in models of abdominal aortic aneurysm.

Purpose: To determine complementary criteria to existing morphological criteria, which are not reliable but are used to justify surgical intervention to treat abdominal aortic aneurysm (AAA).

Methods: An experimental study was conducted in which 2 models of AAA, 1 rigid and 1 soft, were used to study the influence of compliance on aneurysm dynamics. The heart rate was 70 beats per minute, and the mean flow rate was 1.

Flow behaviour in an asymmetric compliant experimental model for abdominal aortic aneurysm.

An experimental study was carried out on asymmetrical abdominal aortic aneurysm (AAA) to analyse the physiological flows involved. Velocity measurements were performed using particle image velocimetry. Resting and exercise flow rates were investigated in models with rigid and compliant walls to assess the parameters affecting the flow behaviour.

New insights into the assessment of the prosthetic valve performance in the presence of subaortic stenosis through a fluid-structure interaction model.

The aim of this study was to contribute to improving the accuracy of clinical assessments of valve performance in situations involving the concomitant presence of a prosthetic valve and subaortic stenosis (SAS). Physiological flow in a two-dimensional model for a bileaflet mechanical heart valve was investigated numerically in terms of the fluid-structure interactions. The fluid dynamics in a model with SAS of the left ventricle outflow tract were compared with those given by a healthy model.