Dexmedetomidine Use in a Tertiary Care NICU: A Descriptive Study.

Background: Continuous infusions of dexmedetomidine are increasingly used for sedation in critically ill pediatric patients. Emerging data suggest potential benefits when used for sedation in neonates, including reduced sedative requirements and earlier enteral feeds.

Objective: To describe the use, adverse effects, and signs of withdrawal in a cohort of neonates receiving dexmedetomidine, the majority of whom were receiving concomitant opioids.

Dexmedetomidine Use in a Pediatric Intensive Care Unit: A Retrospective Cohort Study.

Background: Use of dexmedetomidine in critically ill pediatric patients is increasing despite limited data on effects on mechanical ventilation times, use of other sedatives, adverse effects, and withdrawal.

Objectives: To describe the use and tolerability of dexmedetomidine in a large cohort of critically ill children.

Methods: This was a retrospective cohort study of patients receiving dexmedetomidine in a pediatric intensive care unit.

Levofloxacin Use in the Neonate: A Case Series.

We report 6 cases of intravenous levofloxacin use to treat multidrug-resistant nosocomial respiratory infections in neonates with a postmenstrual age ranging from 27 to 42 weeks. Because of a lack of neonatal-specific information for levofloxacin, the usual pediatric dosage (10 mg/kg per dose every 12 hours) was used in these patients. Clinical cure occurred in 5 of the 6 patients.