Publications by authors named "Deok Hoon Kim"
Purpose: Neuroendocrine carcinomas (NECs) of the stomach are extremely rare, but fatal. However, our understanding of the genetic alterations in gastric NECs is limited. We aimed to evaluate genomic and clinicopathological characteristics of gastric NECs and mixed adenoneuroendocrine carcinomas (MANECs).
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- - The study focuses on the increasing significance of exon 20 insertion mutations (E20ins) in EGFR and HER2 within non-small cell lung cancer (NSCLC) patients, highlighting the growing number of targeted therapies available for these mutations.
- - Between December 2013 and July 2021, researchers identified E20ins in 107 patients, with a notable discordance rate of 53.1% between identification methods (PCR and NGS) for EGFR mutations, indicating the importance of using advanced testing methods like NGS for accurate detection.
- - The results showed that targeted therapies for E20ins significantly outperformed traditional platinum-based treatments, achieving better objective response rates and progression-free survival, underscoring