Publications by authors named "Deog-Kyeom Kim"
Article Synopsis
- - The study analyzed 3,252 COPD patients in South Korea to evaluate the prevalence and significance of airflow obstruction before and after bronchodilator treatment, revealing that most patients (96.2%) fell into the pre-bronchodilator and post-bronchodilator obstruction category.
- - Over three years, approximately 21.6% of patients faced moderate-to-severe exacerbations, but the risk was not statistically significant after adjustments; other outcomes, like GOLD group progression and FEV₁ decline, showed no major differences linked to bronchodilator treatment.
- - The findings suggest that pre-bronchodilator spirometry is effective for screening COPD, though the initial higher exacerbation risk associated with combined obstruction faded upon further
Impulse oscillometry (IOS) is a sensitive tool for assessing small airway function in patients with chronic obstructive pulmonary disease (COPD). This study aimed to differentiate between COPD, small airway disease (SAD), and normal groups using IOS, and to evaluate the clinical applicability of IOS. This retrospective cohort study was conducted from January 2020 to February 2022.
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- The Leicester Cough Questionnaire (LCQ) is a tool for assessing cough that includes physical, psychological, and social aspects, but some items may not fit their assigned domains well.
- This study aimed to improve the coherence of item classifications in the Korean version of the LCQ (K-LCQ) using retrospective data analysis and statistical methods.
- The results showed that the reclassification of six items led to better alignment within domains, enhancing the overall correlation coherence of the questionnaire.
Article Synopsis
- Chronic cough is a common problem, affecting about 9.6% of people worldwide, with more women than men experiencing it.
- A study in South Korea looked at 625 adult patients to see how chronic cough differs between men and women based on age and causes.
- Results showed that women were generally older, more often had asthma-related coughs, and even though the severity was similar, the prevalence of cough increased significantly in women as they got older.
Article Synopsis
- This study compared data from a multicenter cohort study and nationwide respiratory virus data to assess whether they represent similarities in causative factors for COPD and asthma exacerbations.
- The results showed strong correlations between respiratory viruses (like RSV and influenza) in both data sources, with some showing high synchronicity while others indicated low synchronicity.
- It also found distinct seasonal patterns for these viruses, confirming that this was the first study to analyze and report the relationship between cohort study data and nationwide surveillance on respiratory viruses.
Article Synopsis
- Phlegm is a common issue for patients with COPD, and this study investigated the effect of N-acetylcysteine (NAC) nebulizer therapy on reducing this symptom over 12 weeks.
- A total of 100 COPD patients participated in the trial, showing a significant reduction in phlegm scores from 3.47 to 2.62 after treatment, with over half of the patients reporting satisfaction.
- The study concluded that nebulized NAC is both effective and safe, with only a small number of patients experiencing mild adverse events.
Background: COPD primarily impairs expiratory flow due to progressive airflow obstruction and reduced lung elasticity. Increasing evidence underlines the importance of inspiratory flow as a biomarker for selecting inhaler devices and providing ancillary aerodynamic information.
Research Question: Do the longitudinal changes in maximum forced inspiratory flow (FIFmax) influence acute exacerbations and lung function decline in patients with COPD?
Study Design And Methods: This longitudinal study evaluated FIFmax in patients with COPD over a 7-year period from 2004 to 2020.
Background: Mucus plugs identified through chest computed tomography (CT) scans have emerged as potential prognostic factors in chronic obstructive pulmonary disease (COPD). This 5-year longitudinal study investigated their impact on exacerbations and FEV decline.
Methods: COPD patients with baseline chest CT and spirometric assessments were categorized based on mucus plug presence.
Objective: We aimed to elucidate the clinical factors associated with acute exacerbation and disease progression in young patients with chronic obstructive pulmonary disease (COPD).
Methods: This retrospective longitudinal observational study included patients with COPD aged between 20 and 50 years with post-bronchodilator forced expiratory volume in one second (FEV)/forced vital capacity (FVC)<0.7.
Background: Acute bronchitis is the most common respiratory disease. Mixture of Ivy Leaf Extract and Coptidis rhizome syrup has shown good treatment efficacy against chronic bronchitis and acute respiratory infections. This study aimed to evaluate the efficacy and safety of Mixture of Ivy Leaf Extract and Coptidis rhizome compared with those of extract, for the treatment of acute bronchitis.
View Article and Find Full Text PDFBackground: Sex-related disparities in the prevalence of chronic cough have been consistently reported globally, with varying male-to-female ratios.
Objectives: This study aimed to evaluate sex-related differences by comparing correlations between cough-related symptoms in males and females of different age groups.
Design: Adult patients with chronic cough who completed the Leicester Cough Questionnaire (LCQ) were recruited from 16 respiratory centers.
Eosinophilia Is a Favorable Marker for Pneumonia in Chronic Obstructive Pulmonary Disease.
Tuberc Respir Dis (Seoul)
October 2024
Background: Patients with chronic obstructive pulmonary disease (COPD) expressing eosinophilia experience slightly fewer episodes of community-acquired pneumonia (CAP), than those without eosinophilia. However, the severity and burden of hospitalized pneumonia patients with COPD involving eosinophilia have not been assessed.
Methods: We evaluated the differences in clinical characteristics between patients with CAP and COPD with or without eosinophilia by a post hoc analysis of a prospective, multi-center, cohort study data.
Background: Different progressions or prognoses of chronic obstructive pulmonary disease (COPD) have been reported according to structural abnormalities based on chest computed tomography (CT). This study aimed to investigate whether different structural abnormalities independently affect annual lung function changes and clinical prognosis in patients with COPD.
Methods: This longitudinal multicenter observational study was conducted using the KOCOSS cohort (NCT02800499) database in Korea from January 2012 to December 2019.
Background: Roflumilast is effective in reducing acute exacerbation in patients with chronic obstructive pulmonary disease (COPD) at high risk of severe exacerbation. Clinical traits related to the benefits of roflumilast need to be evaluated in patients with COPD.
Methods: A longitudinal observational study in patients newly diagnosed with COPD was conducted using claims data from the Health Insurance Review and Assessment Service in South Korea from 2012-2020 after a 2-year washout period.
Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry.
Int J Chron Obstruct Pulmon Dis
February 2024
Article Synopsis
- PRISm (Preserved ratio impaired spirometry) is a complicated lung condition that’s not well-studied in terms of its prevalence or long-term outlook, prompting a comparison with chronic obstructive pulmonary disease (COPD).
- In a study involving 623 patients (40 with PRISm and 583 with COPD), PRISm patients were generally younger, more likely to be female, and had fewer severe illnesses compared to COPD patients, but showed similar risks for acute lung exacerbations.
- Throughout the follow-up period, PRISm patients experienced a slower decline in lung function compared to those with COPD, suggesting a potentially different trajectory in disease progression.
Background And Objective: When multiple complex air pollutants are combined in real-world settings, the reliability of estimating the effect of a single pollutant is questionable. This study aimed to investigate the combined effects of changes in air pollutants on small airway dysfunction (SAD).
Methods: We analysed Korea National Health and Nutrition Examination Survey (KNHANES) V-VIII database from 2010 to 2018 to elucidate the associations between annual changes in air pollutants over a previous 5-year period and small airway function.
A weak correlation between diffusing capacity of the lung for carbon monoxide (DL) and emphysema has been reported. This study investigated whether impaired DL in chronic obstructive pulmonary disease (COPD) is associated with increased risk of acute exacerbation independent of the presence or extent of emphysema. This retrospective cohort study included patients with COPD between January 2004 and December 2019.
View Article and Find Full Text PDFBackground: Global Lung Function Initiative (GLI)-2012 reference equation is currently suggested for interpretation of spirometry results and a new local reference equation has been developed in South Korea. However, lung function profiles according to the different reference equations and their clinical relevance have not been identified in chronic obstructive pulmonary disease (COPD) patients.
Methods: Our cross-sectional study evaluated Choi's, Korean National Health and National Examination Survey (KNHANES)-VI, and GLI-2012 reference equations.
Background And Objectives: Few studies have reported which inhaled combination therapy, either bronchodilators and/or inhaled corticosteroids (ICSs), is beneficial in patients with bronchiectasis and airflow obstruction. Our study compared the efficacy and safety among different inhaled combination therapies in patients with bronchiectasis and airflow obstruction.
Methods: Our retrospective study analyzed the patients with forced expiratory volume in 1 s (FEV)/forced vital capacity < 0.
Background: Sarcopenia is a risk factor for pneumonia in the elderly, and the timed up-and-go test (TUG) can be used as a screening tool for sarcopenia in this population. This study aimed to evaluate the association between TUG test results and future pneumonia or ventilator care.
Materials And Methods: From the National Health Insurance Service-Senior Cohort database, we identified 19,804 people without neurological diseases who underwent the TUG test in the National Screening Program for Transitional Ages at the age of 66 years during 2007-2008.
Development of the Rapid Cough Questionnaire: Key item identification.
Ann Allergy Asthma Immunol
April 2024
Background: The Leicester Cough Questionnaire (LCQ) is a reliable tool for measuring the multidimensional impact of cough on patients' quality of life; however, its scoring algorithm is lengthy and complex for routine clinical use.
Objective: The study aimed to develop a simplified version of the LCQ, the Rapid Cough Questionnaire (RCQ), as a substitue in clinical practice and validate the RCQ using an independent cohort.
Methods: To select items for the RCQ score, a correlation network was used to determine the items from each domain that were strongly correlated with the total LCQ score.
Background: Poor uptake to pulmonary rehabilitation (PR) is still challenging around the world. There have been few nationwide studies investigating whether PR impacts patient outcomes in COPD. We investigated the change of annual PR implementation rate, medical costs, and COPD outcomes including exacerbation rates and mortality between 2015 and 2019.
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- Researchers studied how cough severity and characteristics differ among various causes of chronic cough in 220 adult patients.
- They used a correlation network analysis to explore the relationships between demographic factors (like age and sex) and cough characteristics linked to conditions like asthma, GERD, and eosinophilic bronchitis.
- Findings indicated that cough severity decreases with age, varies by gender, and that different conditions (e.g., asthma and GERD) show unique associations with sleep disturbance and fatigue.
Background/aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not been evaluated in the post-era of pneumococcal vaccination in Korea.
Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals.