Publications by authors named "Denshi Takai"
Viral infections in patients with post-kidney transplantation are often difficult to diagnose as well as treat. We herein report three cases with severe viral infections after kidney transplantation. All their causative pathogens could be detected promptly by polymerase chain reaction and flow cytometry during the early stages of infection.
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- Coxsackievirus A6 (CV-A6) is an enterovirus causing herpangina and has become linked to hand, foot, and mouth disease (HFMD) outbreaks in Japan, particularly in 2011 and 2013.
- A study analyzed the full-length genomes of CV-A6 strains from 5,612 children with suspected enterovirus infections, identifying 127 cases of CV-A6 through genetic sequencing.
- Phylogenetic analyses showed two clusters of CV-A6 strains: one associated with herpangina (1999-2009) and another linked to HFMD outbreaks (2011-2013), indicating significant genomic changes over time that may influence clinical outcomes.
The conversion of soluble, nontoxic amyloid beta-protein (Abeta) to aggregated, toxic Abeta rich in beta-sheet structures is considered to be the key step in the development of Alzheimer's disease. Therefore, extensive studies have been carried out on the mechanisms involved in Abeta aggregation and the characterization of Abeta aggregates formed in aqueous solutions mimicking biological fluids. On the other hand, several investigators pointed out that membranes play an important role in Abeta aggregation.
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