Topical nitroglycerin is associated with a reduced mastectomy skin flap necrosis-systematic review and meta-analysis.

Introduction: The flap necrosis rate remains high despite the advancement of technology in daily practices. Several randomized trials of topical Nitroglycerin (NTG) have shown promise in reducing flap necrosis. We aim to evaluate the efficacy and safety of topical NTG in preventing flap failure based on existing databases.