PeptideForest: Semisupervised Machine Learning Integrating Multiple Search Engines for Peptide Identification.

The first step in bottom-up proteomics is the assignment of measured fragmentation mass spectra to peptide sequences, also known as peptide spectrum matches. In recent years novel algorithms have pushed the assignment to new heights; unfortunately, different algorithms come with different strengths and weaknesses and choosing the appropriate algorithm poses a challenge for the user. Here we introduce PeptideForest, a semisupervised machine learning approach that integrates the assignments of multiple algorithms to train a random forest classifier to alleviate that issue.

Falls and fractures in men with prostate cancer taking second-generation androgen receptor antagonists: A retrospective chart review.

Introduction: Second-generation androgen receptor antagonists, including enzalutamide, apalutamide, and darolutamide, are commonly used to treat metastatic and non-metastatic prostate cancer. Although these medications are typically well-tolerated, falls were reported in 4.2-15.

A hop testing alternative for functional performance following anterior cruciate ligament reconstruction.

The purpose of this work was to provide a simple method to determine reactive strength during the 6-meter timed hop test (6mTH) and evaluate its association with isokinetic peak torque in patients following anterior cruciate ligament reconstruction (ACLR). Twenty-nine ACLR patients who were at least four months from surgery were included in this analysis. Participants were brought into the laboratory on one occasion to complete functional testing.

A pilot study of a brief and scalable psychosocial intervention for children and adolescents following disasters.

Objectives: Following disaster exposure, a significant proportion of children/adolescents will develop levels of post-traumatic stress symptoms (PTSS) that do not meet diagnostic threshold for PTSD, but which cause ongoing distress. This paper describes the development and pilot testing of a brief, scalable, psychosocial intervention. SOLAR-Kids/Teens has been designed to be delivered by non-mental health professionals ('coaches') to children/adolescents experiencing moderate levels of PTSS following disasters.

Performance, combustion and emission reduction characteristics of Metal-based silicon dioxide nanoparticle additives included in ternary fuel (diesel-SMME-iso butanol) on diesel engine.

Biodiesel has long been recognized as a viable alternative energy source. In order to enhance the quality, and performance of biodiesel-diesel fuel blends while reducing air pollution from combustion, additives must be employed. The present research aims to focus on the addition of SiO novel nanoparticles (at a concentration of 30, 60, and 90 mg/L) in the ternary fuel (TF) blend (75% of Diesel+ 15% of Sea Mango Methyl Ester (SMME15) + 10% of iso-Butanol on a volume basis) to determine engine performance, combustion, and emission characteristics of a 1-cylinder, direct injection, liquid-cooled, diesel engine.

Addressing Housing-Related Social Needs Through Medicaid: Lessons From North Carolina's Healthy Opportunities Pilots Program.

North Carolina Medicaid's Healthy Opportunities Pilots program is the country's first comprehensive program to evaluate the impact of paying community-based organizations to provide eligible Medicaid enrollees with an array of evidence-based services to address four domains of health-related social needs, one of which is housing. Using a mixed-methods approach, we mapped the distribution of severe housing problems and then examined the design and implementation of Healthy Opportunities Pilots housing services in the three program regions. Four cross-cutting implementation and policy themes emerged: accounting for variation in housing resources and needs to address housing insecurity, defining and pricing housing services in Medicaid, engaging diverse stakeholders across sectors to facilitate successful implementation, and developing sustainable financial models for delivery.

A precision neuroscience approach to estimating reliability of neural responses during emotion processing: Implications for task-fMRI.

Recent work demonstrating low test-retest reliability of neural activation during fMRI tasks raises questions about the utility of task-based fMRI for the study of individual variation in brain function. Two possible sources of the instability in task-based BOLD signal over time are noise or measurement error in the instrument, and meaningful variation across time within-individuals in the construct itself-brain activation elicited during fMRI tasks. Examining the contribution of these two sources of test-retest unreliability in task-evoked brain activity has far-reaching implications for cognitive neuroscience.

Dataset of manual metal arc welded heterogeneous thin steel plates AISI1018 AND AISI4340.

Advancement in technology demands the joining of heterogeneous metals of low and high-carbon steel grades. In this investigation, AISI1018 low and AIS4340 medium carbon steels were welded to form a heterogeneous thin metal joint using the Manual Metal Arc Welding (MMAW) method. Experimental variations of welding current, electrode position, and weld orientation are selected as the MMAW parameters.

Updates in the Treatment of Non-Metastatic Castrate-Resistant Prostate Cancer: The Benefit of Second-Generation Androgen Receptor Antagonists.

Objective: To review pharmacology, efficacy, safety, and considerations for use, of second-generation androgen receptor (AR) antagonists in treatment of nonmetastatic castrate-resistant prostate cancer (M0CRPC).

Data Sources: Conducted search in PubMed and Google scholar (January, 1, 2002-December 31, 2022), using relevant terms.

Study Selection And Data Extraction: Relevant English-language studies, conducted in humans evaluating second-generation AR antagonists for M0CRPC, and additional articles and package inserts were considered.

Oral Health Policy and Improvement Strategies in Oklahoma.

Oklahoma an ethnically, financially and geographically diverse population has unique oral health care challenges. These challenges include poor overall oral health, inadequate oral health coverage, significant physical access to care barriers and a shortage of oral health care workers. Just as the oral health care barriers are diverse, so are the potential solutions.

Inpatient rehabilitation wheelchair management quality improvement project: Implications for patients with spinal cord injury.

Evaluate hospital fleet wheelchair (WC) requests submitted by physical therapists (PT) for patients with spinal cord injury (SCI) to trial and use during inpatient rehabilitation. Quality improvement project secondary analysis of delivery process and WC trials. Urban inpatient rehabilitation hospital.

2022 National Standards for Diabetes Self-Management Education and Support.

Purpose: The National Standards for Diabetes Self-Management Education and Support (DSMES) provide guidance and evidence-based, quality practice for all DSMES services. Due to the dynamic nature of health care and diabetes research, the National Standards are reviewed and revised approximately every 5 years by key stakeholders and experts within the diabetes care and education community. For each revision, the Task Force is charged with reviewing the current National Standards for appropriateness, relevance, and scientific basis and making updates based on current evidence and expert consensus.

The great leveller? COVID-19's dynamic interaction with social inequalities in the UK.

It has been claimed that the global pandemic is a 'great equaliser' that creates a sense of cohesion, however, this is problematic since COVID-19 has revealed the stark divisions in our societies. For instance, in the UK COVID-19 has hit northern cities particularly hard. Therefore, by focusing on the north of England, and Bradford especially, this paper offers suggestions which may help us see clearly through COVID-19, creating a future that is more equitable.

A year in the social life of a teenager: Within-person fluctuations in stress, phone communication, and anxiety and depression.

Stressful life events (SLEs) are strongly associated with the emergence of adolescent anxiety and depression, but the underlying mechanisms remain poorly understood, especially at the within-person level. We investigated how adolescent social communication (i.e.

Data-set of academic difficulties among students in western Uganda during COVID-19 induced lockdown.

This academic research explicit the data-set of academic difficulties among different age groups of students studying in various schools, colleges or Universities during the COVID-19 induced lockdown. The western part of Uganda comprises 26 districts and the survey was conducted in those regions employing a simple random sampling technique. The dataset is descriptive and an aggregate of 405 students participated in this survey.

Survey on general awareness, mental state and academic difficulties among students due to COVID-19 outbreak in the western regions of Uganda.

This academic research is carried out to access the general awareness, mental state and academic difficulties among different age groups of students studying in various schools, colleges, or Universities during this lockdown period due to the COVID-19 crisis in the western regions of Uganda. An aggregate of 405 students participated in this survey. Among them 253 students are from rural regions, 59 students are from semi-urban regions and 93 students are from urban regions.

Data-set collected during turning operation of AISI 1045 alloy steel with green cutting fluids in near dry condition.

This work is to explicate the data collected during the turning of AISI 1045 alloy steel components in near dry condition with emulsified cutting fluids prepared from cooking oils such as Palm oil and Peanut oil. The base oils are tested for its relative density, viscosity and flash point following ASTM standards. Highly influencing turning factors are identified and the experiments are planned and arranged using Taguchi's L(3) orthogonal array, the experiments are repeated to reduce the errors.

Within-person fluctuations in stressful life events, sleep, and anxiety and depression symptoms during adolescence: a multiwave prospective study.

Background: Adolescence is characterized by substantial changes in sleep behavior, heightened exposure to stressful life events (SLEs), and elevated risk for internalizing problems like anxiety and depression. Although SLEs are consistently associated with the onset of internalizing psychopathology, the mechanisms underlying this relationship remain poorly understood, especially at the within-person level. Here, we leverage a high-frequency longitudinal design to examine sleep as a potential mechanism linking SLEs to increases in anxiety and depression symptoms over a one-year period.

Obesogenic Behaviors and Depressive Symptoms' Influence on Cardiometabolic Risk Factors in American Indian Children.

Background: American Indian (AI) populations suffer disproportionately from cardiovascular disease and depression as compared to other racial/ethnic groups. Behaviors that contribute to obesity are considered obesogenic and include poor diet, low physical activity, and high screen time. This study examined the relationship between depressive symptoms and obesogenic behaviors on cardiometabolic risk factors in AI youth.