Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double-blind, randomized, placebo-controlled trial.

Aim: This was a double-blind, placebo-controlled randomized study investigating whether melatonin can protect against radiation dermatitis in women receiving radiation therapy for primary breast cancer.

Methods: Patients were included before radiation therapy and followed once weekly throughout treatment with a 3-week follow-up. Patients applied 1 g of cream to the irradiated skin twice daily, consisting of either 25 mg/g melatonin and 150 mg/g dimethyl sulfoxide, or placebo.

[Not Available].

Introduction: The use of abbreviations in patient records in Danish hospitals is extensive. The purpose of this study was to investigate the use of abbreviations, how they affect the comprehension, and how much time was saved writing abbreviations.

Methods: The study consisted of four sub-studies.

Quality-of-life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double-blind, randomized, placebo-controlled trial.

The aim of this double-blind, placebo-controlled, randomized study was to investigate whether topical melatonin administered during radiation therapy could increase the quality of life in patients with primary breast cancer. Patients were followed from the first radiation fraction until 3 weeks after the last. The patients applied 1 g of cream to the irradiated area of the skin twice daily, consisting of either 25 mg/g melatonin and 150 mg/g dimethyl sulfoxide, or a placebo cream.

Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial.

Background: Preoperative anxiety is a common issue in surgery. Preoperative anxiety may lead to increased mortality, pain and dissatisfaction with surgery. Melatonin is a drug with only mild adverse effects and has previously been shown to reduce anxiety and pain in the perioperative setting.

Postoperative outcomes that matter to patients undergoing inguinal hernia repair: A qualitative study.

Background: The purpose was to explore which postoperative outcomes are important to patients operated for inguinal hernia to gain a better insight into the patient experience going through surgery.

Methods: A qualitative study was performed using semistructured individual interviews. Participants were all male and had undergone inguinal hernia repair.

Open thrombectomy and retrograde mesenteric stenting as a treatment for acute in chronic occlusive mesenteric ischemia: A case report.

In this case report, we outline a tailored approach for a complex patient with acute in chronic proximal occlusive mesenteric disease complicated with fresh thrombosis and a heavily calcified aorta, where the standard treatment proved suboptimal. We outline the surgical considerations that ultimately led to performing a hybrid procedure of open thrombectomy combined with retrograde open mesenteric stenting of the superior mesenteric artery. The patient was a 75-year-old male, with a history of severe arteriosclerosis presenting with abdominal pain over 48 h.

[Christmas article: Flying fattens and swimming slims - the secret of the mermaid].

INTRODUCTION We aimed to investigate how, changes in atmospheric pressure influence the human body. METHODS The study was an observational study, reported according to the STROBE-guideline (STrengthening the Reporting of OBservational studies in Epidemiology). Participants had their abdominal circumference measured on ground level, at the bottom of a pool, and during flight.

Melatonin for preoperative and postoperative anxiety in adults.

Background: Anxiety in relation to surgery is a well-known problem. Melatonin offers an alternative treatment to benzodiazepines for ameliorating this condition in the preoperative and postoperative periods.

Objectives: To assess the effects of melatonin on preoperative and postoperative anxiety compared to placebo or benzodiazepines.

Pharmacokinetics and Safety of Intravenous, Intravesical, Rectal, Transdermal, and Vaginal Melatonin in Healthy Female Volunteers: A Cross-Over Study.

Introduction: We aimed to investigate the pharmacokinetic properties and safety of melatonin administered by alternative routes of administration.

Methods: This study employed a cross-over design in healthy female volunteers. Twenty-five milligrams of melatonin was administered intravenously, intravesically, rectally, transdermally, and vaginally.

Patient-Reported Outcome Measures for Patients Undergoing Inguinal Hernia Repair.

There are many ways to determine the success of an inguinal hernia operation. Traditional measures are hernia recurrence, neuralgia, mesh infection, or rather the absence of these complications. While these traditional measures obviously have their merits, alternative outcomes are emerging, and researchers and clinicians are gaining an increasing interest in patient-reported outcomes and patient reported outcome measures (PROMs).

Patient-reported outcome measures for inguinal hernia repair are insufficiently validated: a systematic review.

Purpose: To systematically assess the validity of patient-reported outcome measures (PROMs) for patients undergoing inguinal hernia repair.

Data Sources: A systematic review was performed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline for systematic reviews of PROMs. PubMed, EMBASE and PsycINFO were consulted.

[Sex reassignment surgery in Denmark].

This review summarises the knowledge of sex reassignment surgery in Denmark. Sex reassignment surgery aims at confirming a transgender person's gender identity and can consist of surgery on breasts, genitals, thyroid cartilage, vocal cords as well as facial and body contours. In Denmark, most procedures are performed at a highly specialised level after referral to Center for Gender Identity.

Blondes do not have more fun: a non-blinded crossover field study.

Objectives: To evaluate whether blondes have more fun, as proposed by Sir Roderick David Stewart in 1978.

Design: Prospective, non-randomised crossover field study, 1-2 June 2018.

Setting: Single centre medical writing course, during a break in the course program.

Incisional hernia after cesarean section: A systematic review.

Incisional hernia is a well-known complication following abdominal surgery. A frequently performed abdominal operative procedure is cesarean section. In 2015 the median cesarean section rate in Europe was 27 % with rates up to 57 % when looking at individual countries, and the rates of cesarean sections increased with 4 % in Europe from 2010 to 2015.

Outcome Measures in Gender-Confirming Chest Surgery: A Systematic Scoping Review.

Background: The aim of this scoping review was to provide an overview of outcome measures in gender-confirming chest surgery.

Methods: A comprehensive literature search was performed in PubMed, EMBASE, CINAHL, PsycINFO, Scopus and the Cochrane Library to find studies evaluating gender-confirming chest surgery in a non-cis gender population. The systematic scoping review followed the PRISMA extension for scoping reviews.

Adverse reactions of dimethyl sulfoxide in humans: a systematic review.

Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made.

[Radical prostatectomy increases the incidence of inguinal hernia].

Inguinal hernia is a specific post-operative complication of radical prostatectomy, but so far it has not been reported in Denmark. In this review, we report the incidence of inguinal hernia after both open retropubic and robot-assisted approaches and discuss potential disease mechanisms. Different surgical techniques to prevent development of inguinal hernia after radical prostatectomy have been proposed.

Incidence of Inguinal Hernia after Radical Prostatectomy: A Systematic Review and Meta-Analysis.

Purpose: To investigate the incidence of inguinal hernia following radical prostatectomy we compared the incidence after open retropubic radical prostatectomy with the incidence after the laparoscopic and robot-assisted radical prostatectomies, and using control groups.

Materials And Methods: We included all original articles on studies providing data on inguinal hernia incidence in patients treated with radical prostatectomy for localized prostate cancer. PubMed® and EMBASE® were searched on February 28, 2018.

[Upcoming changes in work-flow, possibilities and challenges as a result of newbuilt Danish hospitals].

Soon, many Danish hospitals will change from shared to single occupancy rooms. Based on the available literature, the aim of this review is to discuss advantages and disadvantages of both room types, as well as the upcoming changes in work-flow for the staff. There are multiple advantages of single occupancy rooms but also some of shared occupancy.

[Prevention of incisional hernia].

Following laparotomies, the rate of incisional hernia is 5-20%, and in high-risk patients more than 30%. The current literature suggests the use of a transverse incision if pos-sible, a suture technique with small bites, and a wound: suture length ratio of 1:4. Recent studies have shown, that the use of prophylactic mesh in an onlay position could have a significant effect on decreasing the rate of incisional hernia.

[A watchful waiting strategy in ventral and inguinal hernias].

In male patients with asymptomatic or minimally symptomatic ventral and inguinal hernias, a watchful waiting strategy should be considered. Even though one third to two thirds of these patients will eventually undergo hernia repair, they may still benefit from a watchful waiting strategy, as hernia repair is associated with a range of complications, e.g.