Biventricular circulatory support using single-device and dual-device configurations: Initial pump characterization in simulated heart failure model.

Objective: Severe biventricular heart failure (BHF) can be remedied using a biventricular assist device (BVAD). Two devices are currently in development: a universal ventricular assist device (UVAD), which will be able to assist either the left, right, or both ventricles, and a continuous-flow total artificial heart (CFTAH), which replaces the entire heart. In this study, the hemodynamic performances of two UVADs are compared to a CFTAH acting as a BVAD.

Evaluation of centrifugal blood pump performances for biventricular support in the virtual simulation model.

Background: Despite the advances in the left ventricular assist device (LVAD), there are still situations that require a biventricular assist device (BVAD) system. The purpose of this study was to explore and compare the system performance interactions with the HeartMate3 (HM3) and HeartWare (HVAD) in a BVAD configuration using the virtual mock loop (VML) simulation tool.

Methods: The VML simulation tool is an in silico implementation of a lumped parameter model of the cardiovascular system with mechanical circulatory support.

Modeling of Virtual Mechanical Circulatory Hemodynamics for Biventricular Heart Failure Support.

Objective: In this study, a mechanical circulatory support simulation tool was used to investigate the application of a unique device with two centrifugal pumps and one motor for the biventricular assist device (BVAD) support application. Several conditions-including a range of combined left and right systolic heart failure severities, aortic and pulmonary valve regurgitation, and combinations of high and low systemic and pulmonary vascular resistances-were considered in the simulation matrix. Relative advantages and limitations of using the device in BVAD applications are discussed.

A simulation tool for mechanical circulatory support device interaction with diseased states.

We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices under various stages of consideration or development at our institution. This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature.

Analysis of Cleveland Clinic continuous-flow total artificial heart performance using the Virtual Mock Loop: Comparison with an in vivo study.

The Virtual Mock Loop (VML) is a mathematical model designed to simulate mechanism of the human cardiovascular system interacting with mechanical circulatory support devices. Here, we aimed to mimic the hemodynamic performance of Cleveland Clinic's self-regulating continuous-flow total artificial heart (CFTAH) via VML and evaluate the accuracy of the VML compared with an in vivo acute animal study. The VML reproduced 124 hemodynamic conditions from three acute in vivo experiments in calves.

Use of a Mechanical Circulatory Support Simulation to Study Pump Interactions With the Variable Hemodynamic Environment.

The Virtual Mock Loop, a versatile virtual mock circulation loop, was developed using a lumped-parameter model of the mechanically assisted human circulatory system. Inputs allow specification of a variety of continuous-flow pumps (left, right, or biventricular assist devices) and a total artificial heart that can self-regulate between left and right pump outputs. Hemodynamic inputs were simplified using a disease-based input panel, allowing selection of a combination of cardiovascular disease states, including systolic and diastolic heart failure, stenosis, and/or regurgitation in each of the four valves, and high to low systemic and pulmonary vascular resistance values.

Simulated Performance of the Cleveland Clinic Continuous-Flow Total Artificial Heart Using the Virtual Mock Loop.

Our new Virtual Mock Loop (VML) is a mathematical model designed to simulate the human cardiovascular system and gauge performance of mechanical circulatory support devices. We aimed to mimic the hemodynamic performance of Cleveland Clinic's self-regulating continuous-flow total artificial heart (CFTAH) via VML and evaluate VML's accuracy versus bench data from our standard mock circulatory loop. The VML reproduced 23 hemodynamic conditions.