Effects of medium-chain triglyceride ingestion on fuel metabolism and cycling performance.

On three occasions separated by 10 days, six endurance-trained cyclists rode for 2 h at 60% of peak O2 uptake and then performed a simulated 40-km time trial (T-trial). During the rides, the subjects ingested a total of 2 liters of a [U-14C]glucose-labeled beverage containing a random order of either 10% glucose [carbohydrate (CHO)], 4.3% medium-chain triglycerides (MCTs); or 10% glucose + 4.

Assessment of the reproducibility of performance testing on an air-braked cycle ergometer.

The purposes of this study were (I) to assess the reproducibility of endurance performance testing on an air-braked cycle ergometer, and (II) to compare laboratory performances to performances in road races. Ten well-trained, competitive cyclists (peak power output [PPO] 443 +/- 37 W, [values are mean +/- SD]) undertook either: (I) three 20 km and three 40 km time trials (TT) on an air braked ergometry system (Kingcycle) (n = 6), and/or (II) three 40 km laboratory TT and two 40 km road TT competitions (n = 8). The time taken for the laboratory simulated 20 km and 40 km TT rides were highly reproducible (coefficient of variation 1.

Fuel substrate kinetics of carbohydrate loading differs from that of carbohydrate ingestion during prolonged exercise.

This study compared fuel substrate kinetics in trained cyclists who ingested a 10% carbohydrate (CHO) drink without prior CHO-loading ([NLC] n=9) with those in cyclists who ingested a water placebo after CHO-loading ([CLP] n=7) during 180 minutes of cycling at 70% maximum oxygen consumption (Vo2 max). Muscle glycogen at the start of exercise was 194 +/- 4 and 124 +/- 8 mmol/kg wet weight (mean +/- SEM) in CLP and NLC subjects, respectively . Total CHO oxidation was similar.

Fuel kinetics during intense running and cycling when fed carbohydrate.

On two occasions, six well-trained, male competitive triathletes performed, in random order, two experimental trials consisting of either a timed ride to exhaustion on a cycle ergometer or a run to exhaustion on a motor-driven treadmill at 80% of their respective peak cycling and peak running oxygen (VO2 max) uptakes. At the start of exercise, subjects drank 250 ml of a 15 g.100 ml-1 w/v [U-14C]glucose solution and, thereafter, 150 ml of the same solution every 15 min.

A canine model for determination of the therapeutic index of cytokine inhibitors.

Using tumor necrosis factor (TNF) inhibition in dog blood as a measure of efficacy, and canine emesis as a measure of toxicity, we were able to assign a therapeutic index to rolipram, a prototypic anti-inflammatory compound. Because both assays were performed in the same species, the ambiguities associated with comparing the physiologic effects of drugs on various species was avoided. Rolipram, a standard phosphodiesterase type IV inhibitor, was a prototypic test compound characterized by a number of cardiovascular and central nervous system side effects, as well as its in vitro and in vivo inhibition of TNF.

Phase I evaluation of zalcitabine administered to human immunodeficiency virus-infected children.

The safety, tolerability, and pharmacokinetics of zalcitabine (ddC) in a single oral dose (0.02 mg/kg) was evaluated in 23 mildly symptomatic human immunodeficiency virus-infected children (mean age, 4.2 years).

Fuel utilisation during prolonged low-to-moderate intensity exercise when ingesting water or carbohydrate.

Previously, we examined the effects of carbohydrate (CHO) ingestion on glucose kinetics during exercise at 70% of maximum O2 uptake (VO2, max). Here we repeat those studies in heavier cyclists (n = 6 per group) cycling for 3 h at a similar absolute O2 uptake but at a lower (55% of VO2, max) relative exercise intensity. During exercise, the cyclists were infused with a 2-3H-glucose tracer and ingested U-14C glucose-labelled solutions of either flavoured water (H2O) or 10 g/100 ml glucose polymer, at a rate of 600 ml/h.

Effects of endurance training on lactate removal by oxidation and gluconeogenesis during exercise.

This report describes the effects of 9 weeks of endurance-training on the relative rates of lactate removal via oxidation and gluconeogenesis in humans. Before and after training, eight subjects performed incremental (60 W plus 40 W every 6 min) exercise tests, while 14C-lactate was infused into one forearm vein and arterialized venous blood was sampled from the other forearm. During the trial, the volume of expired 14CO2 and circulating 14C-lactate and 14C-glucose specific radioactivities were measured.

The relationship between critical power and running performance.

Critical power is a theoretical concept that presumes there is a certain work-rate which may be maintained without exhaustion. The extent to which critical power predicts running performance over varying distances has not been determined, and so the aim of this study was to correlate measurements of critical power in the laboratory to running performances in the field at 40 m and 1, 10 and 21.1 km in a group of .

The effects of carbohydrate loading on muscle glycogen content and cycling performance.

This study compared the effects of supplementing the normal diets of 8 endurance-trained cyclists with additional carbohydrate (CHO), in the form of potato starch, for 3 days on muscle glycogen utilization and performance during a 3-hr cycle ride. On two occasions prior to the trial, the subjects ingested in random order either their normal CHO intake of 6.15 +/- 0.

Role of decreased carbohydrate oxidation on slower rises in ventilation with increasing exercise intensity after training.

In these studies, we examined whether the rightward shift in steady-state minute ventilation (VE) versus O2 uptake curves after training is more closely linked to the reduced CO2 production from carbohydrate oxidation (CHOOX) after training than to the attenuated increase in blood lactate concentration. Steady state VE values and gas exchange were measured in eight previously sedentary men who underwent exercise tests of 60 W + 40 W every 6 min before and after a 9 week training programme of cycling approximately 40 min a day. Following training, the slower rises in VE with increasing exercise intensities were associated with a reduced reliance on CHOOX, (P < 0.

Nutritional practices of athletes: are they sub-optimal?

Athletes' nutritional needs are principally determined by their training load (the intensity x frequency x duration of daily workouts) and body mass. Analyses of the diets of track and field competitors and marathon runners reveal a macronutrient composition similar to that of weight-matched, inactive individuals. Male athletes generally ingest adequate dietary energy to meet their daily energy expenditure and all vitamin and mineral needs.

Water ingestion does not improve 1-h cycling performance in moderate ambient temperatures.

Eight endurance-trained cyclists rode as far as possible in 1 h on a stationary cycle simulator in a moderate environment (20 degrees C, 60% relative humidity, 3 m.s-1 wind speed) while randomly receiving either no fluid (NF) or attempting to replace their approximate 1.71 sweat loss measured in a previous 1-h familiarisation performance ride at approximately 85% of peak oxygen uptake with artificially sweetened, coloured water (F).

Impaired high-intensity cycling performance time at low levels of dehydration.

On two separate occasions six trained subjects (peak oxygen consumption [VO2peak] 4.41/min) rode for 60 min at 70% of VO2peak and then to exhaustion at 90% of VO2peak to determine the effects of mild dehydration on high-intensity cycling performance time in the heat (32 degrees C, 60% relative humidity, wind speed 3 km/h). In one trial (F) subjects ingested a 400 ml bolus of 20 mmol/l NaCl immediately before, and then as repetitive 120 ml feedings every 10 min during the first 50 min of exercise.

Heart rate responses during a 4-d cycle stage race.

The purpose of this study was to monitor the heart rates (HR) of seven, well-trained (maximal oxygen uptake [VO2max] 5.0 +/- 0.5 l.

Carbohydrate, fluid, and electrolyte requirements of the soccer player: a review.

Soccer requires field players to exercise repetitively at high intensities for the duration of game, which can result in marked muscle glycogen depletion and hypoglycemia. A soccer match places heavy demands on endogenous muscle and liver glycogen stores and fluid reserves, which must be rapidly replenished when players complete several matches within a brief period of time. Low concentrations of muscle glycogen have been reported in soccer players before a game, and daily carbohydrate (CHO) intakes are often insufficient to replenish muscle glycogen stores.

Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise.

This study examined effects of ingesting a 10% carbohydrate (CHO) drink (CI) or placebo (PI) at 500 ml/h on total (splanchnic) glucose appearance (endogenous+exogenous; Ra), blood glucose oxidation, and muscle glycogen utilization in 14 male endurance-trained cyclists who rode for 180 min at 70% of maximal O2 uptake after CHO loading [starting muscle glycogen 203 +/- 7 (SE) mmol/kg wet wt]. Total CHO oxidation was similar in CI and PI, but Ra increased significantly during the trial in both groups with CI reaching a plateau after 75 min. Ra was significantly greater in CI than in PI at the end of exercise.

Glucose kinetics during prolonged exercise in euglycaemic and hyperglycaemic subjects.

To determine the limits to oxidation of exogenous glucose by skeletal muscle, the effects of euglycaemia (plasma glucose 5 mM, ET) and hyperglycaemia (plasma glucose 10 mM, HT) on fuel substrate kinetics were evaluated in 12 trained subjects cycling at 70% of maximal oxygen uptake (VO2, max) for 2 h. During exercise, subjects ingested water labelled with traces of U-14C-glucose so that the rates of plasma glucose oxidation (Rox) could be determined from plasma 14C-glucose and expired 14CO2 radioactivities, and respiratory gas exchange. Simultaneously, 2-3H-glucose was infused at a constant rate to estimate rates of endogenous glucose turnover (Ra), while unlabelled glucose (25% dextrose) was infused to maintain plasma glucose concentration at either 5 or 10 mM.

Effects of glucose ingestion or glucose infusion on fuel substrate kinetics during prolonged exercise.

To determine if bypassing both intestinal absorption and hepatic glucose uptake by intravenous glucose infusion might increase the rate of muscle glucose oxidation above 1 g.min-1, ten endurance-trained subjects were studied during 125 min of cycling at 70% of peak oxygen uptake (VO2peak). During exercise the subjects ingested either a 15 g.

Enhanced endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet.

These studies investigated the effects of 2 weeks of either a high-fat (HIGH-FAT: 70% fat, 7% CHO) or a high-carbohydrate (HIGH-CHO: 74% CHO, 12% fat) diet on exercise performance in trained cyclists (n = 5) during consecutive periods of cycle exercise including a Wingate test of muscle power, cycle exercise to exhaustion at 85% of peak power output [90% maximal oxygen uptake (VO2max), high-intensity exercise (HIE)] and 50% of peak power output [60% VO2max, moderate intensity exercise (MIE)]. Exercise time to exhaustion during HIE was not significantly different between trials: nor were the rates of muscle glycogen utilization during HIE different between trials, although starting muscle glycogen content was lower [68.1 (SEM 3.

Superior fatigue resistance of elite black South African distance runners.

Black athletes currently dominate long-distance running events in South Africa. In an attempt to explain an apparently superior running ability of black South African athletes at distances > 3 km, we compared physiological measurements in the fastest 9 white and 11 black South African middle-to long-distance runners. Whereas both groups ran at a similar percentage of maximal O2 uptake (%VO2max) over 1.

Influence of carbohydrate loading on fuel substrate turnover and oxidation during prolonged exercise.

This study compared liver glucose turnover, blood glucose oxidation, and muscle glycogen utilization in 15 male endurance-trained cyclists who rode for 180 min at 70% of maximal O2 consumption in either a carbohydrate-(CHO) loaded (CL) or a non-CHO-loaded (NL) state. Total CHO oxidation during exercise was similar in the CL and NL subjects (492 +/- 77 vs. 448 +/- 43 g, respectively), as were blood glucose oxidation (103 +/- 19 vs.