Publications by authors named "Dennis Howard"
Article Synopsis
- Zoonotic coronaviruses cause severe infections and high mortality, with SARS-CoV-2 being the most deadly despite MERS-CoV having a higher fatality rate.
- Researchers are developing a new series of antiviral inhibitors targeting coronavirus 3CL, which show promising potency and low toxicity.
- High-resolution crystal structures of these inhibitors help understand their binding mechanisms, guiding further optimization for effective treatment.
Redox Biol
September 2023
Article Synopsis
- Identifying new regulators of vascular smooth muscle cell function is key to understanding cardiovascular diseases; the study focuses on cytoglobin, a hemoglobin-like protein with unique roles in blood vessel health.
- Research found that when cytoglobin was deleted in mice, there was a quicker loss of contractile genes and increased DNA damage in injured carotid arteries.
- The study revealed that cytoglobin moves into the nucleus of vascular smooth muscle cells, where it interacts with a chromatin protein called HMGB2, potentially regulating gene expression and protecting against DNA damage.
Article Synopsis
- Identifying new regulators of vascular smooth muscle cell function is crucial for understanding cardiovascular diseases, and cytoglobin has been found to play important roles in this area.
- Studies show that when cytoglobin is deleted, it leads to quicker loss of contractile genes and increased DNA damage in injured carotid arteries.
- The research reveals that cytoglobin moves into the nucleus of vascular smooth muscle cells, interacting with the protein HMGB2 to help prevent DNA damage and regulate gene activity in the vascular system.
