Ameliorative effects of the melatonin on some cytokine levels, NF-κB immunoreactivity, and apoptosis in rats with cerulein-induced acute pancreatitis.

Objectives: Investigating the ameliorative effects of melatonin on cytokine levels, apoptosis, and NF-κB immunoreactivity in rats with cerulein-induced acute pancreatitis.

Materials And Methods: Thirthy-two Wistar Albino rats were divided into four groups: Control group which didn't undergo acute pancreatitis induction and was left without treatment, pancreatitis group in which the acute pancreatitis was induced by 2 successive intraperitoneal doses of cerulein at a 2-hour interval (50 µg/kg and then 25 µg/kg), melatonin-treated pancreatitis group which was intraperitoneally administrated with 50 mg/kg of melatonin, 30 min before each cerulein injection, and melatonin group which was intraperitoneally administrated with 2 successive doses of melatonin (50 mg/kg each) at a 2-hour interval. Pancreatic tissue and blood samples were taken from animals of all groups.

Antioxidant effects of rosemary oil in streptozotocin-induced diabetic rats.

This study designed to investigate the potential effects of rosemary oil on oxidative stress markers in streptozotocin-induced diabetic rats. The rats divided into four groups such as control group, rosemary group, diabetes group and diabetes + rosemary group. Blood samples were analyzed to assess with enzyme-linked immunosorbent assay various parameters including malondialdehyde (MDA), glutathione (GSH), super oxide dismutase (SOD).

The evaluation of curcumin effects on some acute phase proteins in aflatoxin B1 applied rats.

This study was designed to determine the effects of curcumin on some acute phase proteins in rats treated with aflatoxin B1. In this study, healthy 38 male Wistar Albino rats were used. The animals in control group were given food and distilled water.

The effects of bisphenol A on some plasma cytokine levels and distribution of CD8 and CD4 T lymphocytes in spleen, ileal Peyer's patch and bronchus associated lymphoid tissue in rats.

The effects of bisphenol A on the some plasma cytokine levels and distribution of CD8 and CD4 T lymphocytes in spleen, ilealPeyer's patch and bronchus-associated lymphoid tissue in rats were investigated. A total of fourty male Wistar Albino rats were divided into five groups including 8 rats in each one: control, vehicle, BPA 5, BPA 50 and BPA 500 groups. Doses of 5, 50 and 500 μg/kg BPA were dissolved in ethanol, then mixed with corn oil.

Immunohistochemical distribution of heat shock protein 70 and proliferating cell nuclear antigen in mouse placenta at different gestational stages.

The aim of the present study was to investigate immunohistochemical distribution of heat shock protein 70 (Hsp70) and proliferating cell nuclear antigen (PCNA) in the mouse placenta at different gestational stages. For this purpose a total of 18 Swiss albino female mice at 12-14 weeks of age were used. Females were sacrificed on days 3 (early), 10 (mid-), and 17 (late) of pregnancy and the implantation sites of the pregnant uterus were sampled.

Histological and histochemical evaluations on the effects of high incubation temperature on the embryonic development of tibial growth plate in broiler chickens.

The effects of experimentally induced high incubation temperature on the embryonic development of growth plate of the chicken were investigated by means of histological and enzyme histochemical methods. In the experiments, 250 fertile eggs of Ross-308 broiler strain were divided into two groups, the control eggs were maintained under optimal conditions (37.8°C and 65% ± 2% relative humidity, rh) during the whole incubation period.

Effects of ginseng and echinacea on cytokine mRNA expression in rats.

The aim of the study was to determine the effect of ginseng and echinacea on the mRNA expression of IL-10, TNF-α, and TGF-β1 in healthy rats. Six-week-old male Fischer 344 rats (n = 48) were used. The animals were divided into three equal groups, as follows: control (C); ginseng (G); echinacea (E).