The Effect of Five Single Nucleotide Polymorphisms on Hb F Variation of β-Thalassemia Traits and Hematologically Normal Individuals in Southeast Turkey.

β-Thalassemia (β-thal) is caused by deficiency of β-globin chain synthesis and leads to the accumulation of unstable globin chain production. This results in a higher Hb F level in order to neutralize the excess α chains. In addition, γ-globin gene expression, due to genetic factors after birth, leads to increased Hb F levels in adulthood [hereditary persistence of fetal hemoglobin (Hb) (HPFH)].

The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression.

The purpose of the study is to examine the protective effect of resveratrol on the fatty acid synthase gene expression against the side-effects of risperidone in an experimental model in rat liver. In this study, thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, RIS (2 mg/kg risperidone daily), RSV1 (2 mg/kg risperidone + 20 mg/kg resveratrol), RSV2 (2 mg/kg risperidone + 40 mg/kg resveratrol), and RSV3 group (2 mg/kg risperidone + 80 mg/kg resveratrol). On treatment day 15, liver tissue was taken for analysis.

Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol.

Objective: The aim of the study was to investigate the possible protective qualities of resveratrol (RSV) against the side effects of risperidone (RIS) in an experimental model in rat kidneys with histologic and biochemical assessments.

Materials And Methods: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into five groups: control, untreated rats ( = 7) were in group 1; group 2 was given 2 mg/kg/day RIS ( = 7); group 3 was treated with 2 mg/kg/day RIS and 20 mg/kg/day RSV ( = 7); group 4 was treated with 2 mg/kg/day RIS and 40 mg/kg/day RSV ( = 7); and group 5 was treated with 2 mg/kg/day RIS and 80 mg/kg/day RSV ( = 7).

Microchimeric Cells, Sex Chromosome Aneuploidies and Cancer.

The phenomenon of feta-maternal microchimerisms inspires numerous questions. Many questions remain to be answered regarding this new avenue of genetics. The X and Y chromosomes have been associated with malignancy in different types of human tumors.

There is no significant association between death receptor 4 (DR4) gene polymorphisms and lung cancer in Turkish population.

Death receptor 4 (DR4) gene is a candidate tumor suppressor gene that has a role in apoptotic pathway. It was reported in literature that polymorphisms in DR4 gene lead to susceptibility to many cancers. In accordance with this information, we aimed to investigate the association between G422A, C626G, A683C and A1322G polymorphisms in DR4 gene and lung cancer.

Prevalence of beta-thalassemia trait and abnormal hemoglobins in the province of Adıyaman, Turkey.

Background/aims: Thalassemia is one of the most common hereditary disorders in Turkey. The aim of this study was to determine the prevalence of the beta-thalassemia trait and abnormal hemoglobins in the province of Adıyaman in Turkey.

Methods: The study included 3571 high school students of both sexes; aged 12-22 (mean 16.

Prevalence and molecular analysis of β-thalassemia in Adiyaman, Turkey.

Thalassemia is one of the most common hereditary disorders in the Mediterranean region. We report here the results of a premarital screening carried out in Adıyaman in the southeastern region of Turkey, a region with a hitherto unknown incidence of β-thalassemia (β-thal). In order to detect β-thal carrier frequency and genotypes of carriers from the city of Adıyaman, Turkey, both high performance liquid chromatography (HPLC) and the red blood cell counts of 1616 people who applied for premarital tests were analyzed.